Acharya Dilaram, Gaussen Amaury, Poder Thomas G, Lambert Gilles, Renaud Christian, Nawej Karlitaj, Lewin Antoine
Department of Management, Evaluation and Health Policy, School of Public Health, Université de Montréal, Montréal, Québec, Canada.
Medical Affairs and Innovation, Héma-Québec, Montréal, Québec, Canada.
Vox Sang. 2023 Dec;118(12):1029-1037. doi: 10.1111/vox.13521. Epub 2023 Sep 11.
Septic transfusion reactions (STRs) occur as a result of bacterial contamination of blood or blood products, resulting in sepsis. This scoping review aimed to identify, explore and map the available literature on the STR criteria triggering the investigation of STR.
Four electronic databases (MEDLINE, Web of Science, Science Direct, Embase) were searched to retrieve scientific literature reporting such criteria, published from 1 January 2000 to 5 May 2022. Grey literature was also searched from open web sources.
Of 1052 references identified, 43 (21 peer-reviewed and 22 grey literature) met the eligibility criteria for inclusion and data extraction after full article screening. Of them, most (27/43, 62.79%) were found to report a single set of criteria, and only two reported four or more sets of criteria. The analysis of 66 sets of criteria collected from the selected references revealed 57 different sets. A few sets of criteria used only one sign and symptom (s/s) (12.12%, n = 8), whereas 16 sets used 7-15 s/s (n = 16/66; 24.24%). Of the total 319 occurrences of s/s associated with the 66 sets of criteria, post-transfusion hyperthermia, body temperature increase and hypotension were the most common s/s categories. Of all the literature available, only one study tested the diagnostic accuracy of the STR criteria.
This scoping review revealed a substantial variation in criteria used to identify suspected STR. Consequently, conducting further studies to enhance the diagnostic accuracy of these criteria, which trigger STR investigations, is imperative for advancing clinical practice.
脓毒性输血反应（STRs）是血液或血液制品细菌污染导致败血症的结果。本综述旨在识别、探索和梳理有关引发STR调查的标准的现有文献。
检索了四个电子数据库（MEDLINE、Web of Science、ScienceDirect、Embase），以获取2000年1月1日至2022年5月5日发表的报告此类标准的科学文献。还从开放网络来源搜索了灰色文献。
在识别出的1052篇参考文献中，43篇（21篇同行评审文献和22篇灰色文献）在全文筛选后符合纳入和数据提取的资格标准。其中，大多数（27/43，62.79%）报告了一组标准，只有两篇报告了四组或更多组标准。从选定参考文献中收集的66组标准分析显示有57种不同的标准集。少数标准集仅使用一种体征和症状（s/s）（12.12%，n = 8），而16组使用7 - 15种s/s（n = 16/66；24.24%）。在与66组标准相关的319次s/s出现情况中，输血后高热、体温升高和低血压是最常见的s/s类别。在所有现有文献中，只有一项研究测试了STR标准的诊断准确性。
本综述揭示了用于识别疑似STR的标准存在很大差异。因此，开展进一步研究以提高这些引发STR调查的标准的诊断准确性，对于推进临床实践至关重要。
