创伤性脑损伤后血栓性微血管病：一例病例报告及文献综述
Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature.
作者信息
Van Meerbeeck Xavier, Janssen Leen, Vleut Rowena, Verdonck Philip, Gadisseur Alain, De Paep Rudi, Verbrugghe Walter, Jorens Philippe
机构信息
Department of Intensive Care Medicine Antwerp University Hospital, University of Antwerp Edegem Belgium.
Department of Nephrology Antwerp University Hospital, University of Antwerp Edegem Belgium.
出版信息
Clin Case Rep. 2023 Sep 8;11(9):e7838. doi: 10.1002/ccr3.7838. eCollection 2023 Sep.
KEY CLINICAL MESSAGE
This case report supports that trauma can rarely cause thrombotic microangiopathy (TMA). Early recognition is important due to a high mortality of untreated TMA, but diagnosis can be delayed by attributing lab abnormalities as due to blood loss.
ABSTRACT
Major trauma can provoke coagulopathy, ranging from hypo- to hypercoagulation. Thrombotic microangiopathy (TMA), characterized by hemolytic anemia, renal failure, thrombocytopenia, and intravascular hemolysis, results in bleeding tendency but also microvascular thrombosis. We report a rare case of isolated traumatic brain injury leading to TMA treated with plasmapheresis.
关键临床信息
本病例报告支持创伤极少可导致血栓性微血管病（TMA）。由于未经治疗的TMA死亡率高，早期识别很重要，但诊断可能因将实验室异常归因于失血而延迟。
摘要
严重创伤可引发凝血功能障碍，范围从低凝到高凝。血栓性微血管病（TMA）以溶血性贫血、肾衰竭、血小板减少和血管内溶血为特征，不仅导致出血倾向，还会引发微血管血栓形成。我们报告了一例罕见的单纯性创伤性脑损伤导致TMA的病例，该病例采用血浆置换治疗。
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