Vainio E, Collin P, Lehtonen O P
Clin Immunol Immunopathol. 1986 Nov;41(2):295-300. doi: 10.1016/0090-1229(86)90114-5.
Antigliadin antibodies (AGA) of IgG and IgA class were assayed with a modified enzymeimmunoassay in serum samples of 18 patients with gluten-sensitive enteropathy and 30 patients with dermatitis herpetiformis. No difference between antibody amount or avidity of the two groups of patients was observed. Avidity and total amount of AGA were also compared in 15 patients with a recent diagnosis of dermatitis herpetiformis and in 15 patients with a disease history of several years without a proper gluten-free diet. No difference in IgG antibodies was found but the amount of high avidity IgA antibodies was significantly higher in patients with several years' experience of dermatitis herpetiformis than in those with a recent diagnosis. The results indicate that in dermatitis herpetiformis, maturation of IgA response occurs. Further, clinically, maturation of anti-gliadin IgA response during the disease can increase the sensitivity of the patient against diet-derived gliadin.
采用改良酶免疫测定法检测了18例麸质敏感性肠病患者和30例疱疹样皮炎患者血清样本中IgG和IgA类抗麦醇溶蛋白抗体（AGA）。未观察到两组患者抗体量或亲和力的差异。还比较了15例近期诊断为疱疹样皮炎的患者和15例有几年病史且未进行适当无麸质饮食的患者的AGA亲和力和总量。未发现IgG抗体有差异，但有几年疱疹样皮炎病史的患者中高亲和力IgA抗体量显著高于近期诊断的患者。结果表明，在疱疹样皮炎中，IgA反应会发生成熟。此外，在临床上，疾病期间抗麦醇溶蛋白IgA反应的成熟可提高患者对饮食源性麦醇溶蛋白的敏感性。
