BCL9在发育、肿瘤发生和免疫中的Wnt依赖和Wnt非依赖功能：对治疗机会的启示

The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities.

作者信息

Wu Minjie, Dong Heng, Xu Chao, Sun Mengqing, Gao Haojin, Bu Fangtian, Chen Jianxiang

机构信息

College of Pharmacy and Department of Hepatology, Institute of Hepatology and Metabolic Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

出版信息

Genes Dis. 2023 Apr 11;11(2):701-710. doi: 10.1016/j.gendis.2023.03.012. eCollection 2024 Mar.

DOI:10.1016/j.gendis.2023.03.012

PMID:37692512

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10491870/

Abstract

B-cell CLL/lymphoma 9 (BCL9) is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types, mainly through potentiating the Wnt/β-catenin signaling. However, increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles. Herein, we summarized the updates of the canonical and non-canonical functions of BCL9 in cellular, physiological, or pathological processes. Moreover, we also concluded that the targeted inhibitors disrupt the interaction of β-catenin with BCL9 reported recently.

摘要

B细胞慢性淋巴细胞白血病/淋巴瘤9（BCL9）被认为是一种关键的发育调节因子，并且是多种癌症类型中公认的致癌驱动因子，主要是通过增强Wnt/β-连环蛋白信号传导来实现。然而，越来越多的证据表明，BCL9也发挥多种不依赖Wnt的作用。在此，我们总结了BCL9在细胞、生理或病理过程中经典和非经典功能的最新进展。此外，我们还总结了最近报道的靶向抑制剂破坏β-连环蛋白与BCL9相互作用的情况。