Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Comb Chem High Throughput Screen. 2021;24(9):1323-1331. doi: 10.2174/1386207323666201020105736.
It has been a while since the disease of cancer was discovered in 16th and 17th century but still, this disease is one of the most lethal diseases in the world, which is taking a great number of lives every year. Cancer statistics suggest that there are still a lot of improvements that we have to make in the field of cancer treatment in order to overcome this deadly disease. Currently, nanotechnology has provided some more effective methods in this field, which has gained a lot of attention. Novel drug delivery systems that work using nanoparticles might be the answer to many unsolved questions in treating cancer. Chitosan is a natural glucose polymer which has the potential to be utilized as a proper drug carrier due to its advantageous features. Chitosan-based delivery systems are able to affect cancerous cells in many pathways. Wnt signaling pathways, which are one of the most essential ingredients of cancer pathogenesis, can be the target of chitosan nanoformulations. In this paper, we discussed the specific impacts of chitosan and its nanoformulations on each component of the Wnt/catenin pathway. Our conclusions might give novel insights for designing more efficient therapeutic approaches for several kinds of cancer.
自 16 世纪和 17 世纪发现癌症以来已经有一段时间了，但这种疾病仍然是世界上最致命的疾病之一，每年都夺走了大量的生命。癌症统计数据表明，我们仍需在癌症治疗领域做出许多改进，以克服这种致命疾病。目前，纳米技术在该领域提供了一些更有效的方法，引起了广泛关注。使用纳米颗粒的新型药物输送系统可能是解决癌症治疗中许多未解决问题的答案。壳聚糖是一种天然葡萄糖聚合物，由于其有利的特性，具有作为合适药物载体的潜力。基于壳聚糖的输送系统能够通过多种途径影响癌细胞。Wnt 信号通路是癌症发病机制的最重要成分之一，壳聚糖纳米制剂可以作为其靶点。本文讨论了壳聚糖及其纳米制剂对 Wnt/连环蛋白途径的每个组成部分的具体影响。我们的结论可能为设计针对多种癌症的更有效的治疗方法提供新的思路。
