精神分裂症中神经营养因子-3基因多态性及其与疾病严重程度和认知功能障碍的关系。
Neurotrophin-3 gene polymorphism in schizophrenia and its relation with diseases severity and cognitive dysfunction.
作者信息
Keshri Neha, Nandeesha Hanumanthappa, Rajappa Medha, Menon Vikas
机构信息
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
出版信息
J Neurosci Rural Pract. 2023 Jul-Sep;14(3):501-508. doi: 10.25259/JNRP_34_2022. Epub 2023 Jul 20.
OBJECTIVES
Synaptic plasticity markers are known to alter in schizophrenia. The objective of the study was to investigate the genotype and allele frequency of neurotrophin-3 (NT-3) gene polymorphism (rs6489630, rs6332, and rs11063714) and plasma NT-3 levels in schizophrenia and their relation with cognitive status.
MATERIALS AND METHODS
The study was conducted on 216 Schizophrenia patients and 216 controls. Single-nucleotide polymorphism (SNP) of NT-3 and its plasma levels were assessed in both groups. Cognitive status was evaluated using Addenbrooke Cognitive examination-III scores.
RESULTS
The rs6489630 polymorphism was found to be significantly associated with the severity of schizophrenia ( = 0.004). The CT genotype ( = 0.02, OR = 1.631 [1.10-2.43]) and minor allele T ( = 0.004, OR = 1.58 [1.16-2.16]) of rs6489630 conferred an increased susceptibility to develop schizophrenia. The rs6332 variant was found to affect cognitive status significantly in schizophrenia ( = 0.040), and memory dysfunction was seen in individuals with AG ( < 0.01) and AA variant ( = 0.03) of rs6332.
CONCLUSION
We conclude that SNPs of NT-3 enhance the risk of schizophrenia and are related to cognitive dysfunction.
目的
已知精神分裂症患者的突触可塑性标记会发生改变。本研究的目的是调查神经营养因子-3（NT-3）基因多态性（rs6489630、rs6332和rs11063714）的基因型和等位基因频率、精神分裂症患者的血浆NT-3水平及其与认知状态的关系。
材料与方法
对216例精神分裂症患者和216例对照者进行了研究。评估了两组患者NT-3的单核苷酸多态性（SNP）及其血浆水平。使用Addenbrooke认知检查-III评分评估认知状态。
结果
发现rs6489630多态性与精神分裂症的严重程度显著相关（P = 0.004）。rs6489630的CT基因型（P = 0.02，OR = 1.631 [1.10 - 2.43]）和次要等位基因T（P = 0.004，OR = 1.58 [1.16 - 2.16]）使患精神分裂症的易感性增加。发现rs6332变异在精神分裂症中对认知状态有显著影响（P = 0.040），rs6332的AG（P < 0.01）和AA变异个体存在记忆功能障碍（P = 0.03）。
结论
我们得出结论，NT-3的单核苷酸多态性增加了精神分裂症的风险，并与认知功能障碍有关。
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