神经营养素-3基因多态性与双相情感障碍认知功能损害的关系
Relationship of Neurotropin-3 Gene Polymorphism with Cognitive Impairment in Bipolar Disorder.
作者信息
Monisha Muralidharan, Keshri Neha, Nandeesha Hanumanthappa, Menon Vikas
机构信息
Dept. of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Tamil Nadu, India.
Dept. of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Tamil Nadu, India.
出版信息
Indian J Psychol Med. 2025 Feb 2:02537176251314157. doi: 10.1177/02537176251314157.
BACKGROUND
Neurotropin-3 (NT-3), a marker of neural plasticity, is reported to be altered in bipolar disorder (BD). This study was designed to evaluate NT-3 gene polymorphism (rs 6489630, rs 6332, and rs 11063714) in BD and its association with disease severity and cognition.
METHODS
The study included 176 BD cases and 176 controls. All the participants were tested for NT-3 polymorphism and plasma NT-3. ACE-III scores were used to analyze cognition.
RESULTS
The NT-3 polymorphism (rs 6489630) was associated with cognitive impairment in BD ( = .010). The attention score was found to be decreased in the CT genotype ( = .028) when compared to the CC and TT genotypes of the rs6489630 variant. The visuospatial ability score was decreased in the GG genotype ( = .044) compared to the AG genotype of the rs11063714 variant. BD patients with the maniac episode showed a decrease in levels of Neurotrophin-3 in comparison to both the control group ( = .045) and the remission group ( = .017). Plasma NT-3 was associated with the YMRS ( = -0.221, = .003), HDRS ( = 0.209, = .005) and visuospatial ability score ( = 0.180, = .017) in patients with BD.
CONCLUSION
Single nucleotide polymorphisms of NT-3 are associated with cognitive dysfunction in BD.
背景
神经营养因子-3（NT-3）是神经可塑性的标志物，据报道在双相情感障碍（BD）中会发生改变。本研究旨在评估BD中NT-3基因多态性（rs 6489630、rs 6332和rs 11063714）及其与疾病严重程度和认知的关系。
方法
该研究纳入了176例BD患者和176名对照。所有参与者均接受NT-3多态性和血浆NT-3检测。采用ACE-III评分分析认知情况。
结果
NT-3多态性（rs 6489630）与BD中的认知障碍相关（P = 0.010）。与rs6489630变体的CC和TT基因型相比，CT基因型的注意力得分降低（P = 0.028）。与rs11063714变体的AG基因型相比，GG基因型的视觉空间能力得分降低（P = 0.044）。与对照组（P = 0.045）和缓解组（P = 0.017）相比，有躁狂发作的BD患者神经营养因子-3水平降低。BD患者的血浆NT-3与杨氏躁狂量表（P = -0.221，P = 0.003）、汉密尔顿抑郁量表（P = 0.209，P = 0.005）和视觉空间能力得分（P = 0.180，P = 0.017）相关。
结论
NT-3的单核苷酸多态性与BD中的认知功能障碍相关。
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