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帕金森病冻结步态的结构磁共振成像:文献系统综述

Structural magnetic resonance imaging in Parkinson disease with freezing of gait: A systematic review of literature.

作者信息

Suharto Ade Pambayu, Sensusiati Anggraini Dwi, Hamdan Muhammad, Bastiana Dewi Setyaning

机构信息

Department Neurology, Faculty of Medicine, Airlangga University - Dr Soetomo General Hospital, Surabaya, East Java, Indonesia.

Department Radiology, Faculty of Medicine, Airlangga University - Universitas Airlangga Hospital, Surabaya, East Java, Indonesia.

出版信息

J Neurosci Rural Pract. 2023 Jul-Sep;14(3):399-405. doi: 10.25259/JNRP_107_2023. Epub 2023 May 25.

DOI:10.25259/JNRP_107_2023
PMID:37692820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10483193/
Abstract

OBJECTIVE

This review aims to the existing structural neuroimaging literature in Parkinson disease presenting with freezing of gait. The summary of this article provides an opportunity for a better understanding of the structural findings of freezing of gait in Parkinson disease based on MRI.

METHODS

This systematic review of literature follows the procedures as described by the guideline of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

RESULTS

Initial searches yielded 545 documents. After exclusions, 11 articles were included into our study. Current findings of structural MRI on freezing of gait in Parkinson disease are associated with structural damage between sensorimotor-related cortical grey matter structures and thalamus, but not cerebellum and smaller systems, as well as extensive injuries on white matter connecting between those structures.

CONCLUSION

Current findings of structural MRI on freezing of gait in Parkinson disease are associated with structural damage between sensorimotor-related cortical grey matter structures and thalamus, but not cerebellum and smaller systems, as well as extensive injuries on white matter connecting between those structures.

摘要

目的

本综述旨在探讨帕金森病伴冻结步态的现有结构神经影像学文献。本文的总结为基于MRI更好地理解帕金森病冻结步态的结构发现提供了契机。

方法

本系统文献综述遵循系统评价与Meta分析的首选报告项目(PRISMA)指南所述的程序。

结果

初步检索得到545篇文献。排除后,11篇文章纳入我们的研究。帕金森病冻结步态的结构MRI当前发现与感觉运动相关皮质灰质结构和丘脑之间的结构损伤有关,但与小脑和较小系统无关,以及这些结构之间连接白质的广泛损伤。

结论

帕金森病冻结步态的结构MRI当前发现与感觉运动相关皮质灰质结构和丘脑之间的结构损伤有关,但与小脑和较小系统无关,以及这些结构之间连接白质的广泛损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0623/10483193/b51f2fbf0f53/JNRP-14-399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0623/10483193/b51f2fbf0f53/JNRP-14-399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0623/10483193/b51f2fbf0f53/JNRP-14-399-g001.jpg

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引用本文的文献

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NPJ Parkinsons Dis. 2025 Mar 6;11(1):44. doi: 10.1038/s41531-025-00893-5.

本文引用的文献

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Challenges in the diagnosis of Parkinson's disease.帕金森病诊断中的挑战。
Lancet Neurol. 2021 May;20(5):385-397. doi: 10.1016/S1474-4422(21)00030-2.
2
Thalamic morphology predicts the onset of freezing of gait in Parkinson's disease.丘脑形态学可预测帕金森病步态冻结的发作。
NPJ Parkinsons Dis. 2021 Mar 2;7(1):20. doi: 10.1038/s41531-021-00163-0.
3
Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes.帕金森病和非典型帕金森综合征的神经影像学进展
Front Neurol. 2020 Oct 15;11:572976. doi: 10.3389/fneur.2020.572976. eCollection 2020.
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Freezing of gait in Parkinson's disease: pathophysiology, risk factors and treatments.帕金森病冻结步态:发病机制、危险因素和治疗方法。
Transl Neurodegener. 2020 Apr 15;9:12. doi: 10.1186/s40035-020-00191-5. eCollection 2020.
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Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review.神经影像学在帕金森病冻结步态中的研究进展:系统综述。
Neuroimage Clin. 2019;24:102059. doi: 10.1016/j.nicl.2019.102059. Epub 2019 Nov 9.
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Freezing of gait: understanding the complexity of an enigmatic phenomenon.冻结步态:理解这一神秘现象的复杂性。
Brain. 2020 Jan 1;143(1):14-30. doi: 10.1093/brain/awz314.
7
Freezing of gait in Parkinson's disease reflects a sudden derangement of locomotor network dynamics.帕金森病中的冻结步态反映了运动网络动力学的突然紊乱。
Brain. 2019 Jul 1;142(7):2037-2050. doi: 10.1093/brain/awz141.
8
Gait and postural disorders in parkinsonism: a clinical approach.帕金森病中的步态和姿势障碍:临床处理方法
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9
Abnormal Cerebellar Connectivity Patterns in Patients with Parkinson's Disease and Freezing of Gait.帕金森病伴冻结步态患者小脑连接模式异常。
Cerebellum. 2019 Jun;18(3):298-308. doi: 10.1007/s12311-018-0988-4.
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Freezing of gait in Parkinson's disease: gray and white matter abnormalities.帕金森病冻结步态:灰质和白质异常。
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