腹侧间脑萎缩与帕金森病的步态冻结有关：两个队列的分析。
Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson's disease: analysis of two cohorts.
作者信息
Wang Xuemei, Chen Huimin, Ma Xinxin, Liu Huijing, Wu Dongdong, Du Wei, He Jing, Li Shuhua, Chen Haibo, Wu Tao, Feng Tao, Su Wen
机构信息
Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
NPJ Parkinsons Dis. 2025 Mar 6;11(1):44. doi: 10.1038/s41531-025-00893-5.
Evidence regarding brain structural atrophy associated with Freezing of Gait (FOG) in Parkinson's disease (PD) is inconsistent. We analyzed cortical thickness and subcortical nuclei volumes using FreeSurfer in two large PD cohorts. In cohort 1 (N = 316), multivariate analyses identified reduced pallidum and ventral diencephalon (VDC) volumes as significantly associated with FOG presence. Validation in the Parkinson's Progression Markers Initiative (PPMI) cohort (cohort 2, N = 94) demonstrated that decreased VDC volume at four-year follow-up independently predicted higher FOG risk, improving the predictive model's accuracy when combined with PIGD score, CSF Aβ42, and caudate DAT uptake (AUC 0.760; Δχ = 5.449, P = 0.020; Z = 2.211, P = 0.027). VDC volume is also correlated with FOG severity. These findings suggest that VDC atrophy may underlie FOG mechanisms and serve as a biomarker for its progression in PD patients.
关于帕金森病（PD）中与冻结步态（FOG）相关的脑结构萎缩的证据并不一致。我们在两个大型PD队列中使用FreeSurfer分析了皮质厚度和皮质下核体积。在队列1（N = 316）中，多变量分析确定苍白球和腹侧间脑（VDC）体积减小与FOG的存在显著相关。在帕金森病进展标志物倡议（PPMI）队列（队列2，N = 94）中的验证表明，四年随访时VDC体积减小独立预测更高的FOG风险，与姿势不稳和步态障碍（PIGD）评分、脑脊液Aβ42和尾状核多巴胺转运体摄取相结合时可提高预测模型的准确性（曲线下面积[AUC]为0.760；Δχ = 5.449，P = 0.020；Z = 2.211，P = 0.027）。VDC体积也与FOG严重程度相关。这些发现表明，VDC萎缩可能是FOG机制的基础，并可作为PD患者FOG进展的生物标志物。
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