Zhu Qing, Zhang Jingwen, Xu Derong, Zhao Rui
Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University Nanchang, Jiangxi, China.
Am J Transl Res. 2023 Aug 15;15(8):5339-5346. eCollection 2023.
To investigate the relationship between PD-L1, Ki-67 and the association between PD-L1, Ki-67, and clinicopathologic features and laboratory parameters in the peripheral blood of non-small cell lung cancer (NSCLC) patients.
The clinical records of 213 NSCLC patients were retrospectively reviewed. The patients were divided into high or low expression groups by cut-off values of Ki-67 and PD-L1. Correlation of PD-L1 and Ki-67 expression were analyzed by linear regression analysis. The data were tested by Mann-Whitney test. Relationship of PD-L1 and Ki-67 was tested by chi-square test.
Linear regression analysis revealed a positive association between the expression of PD-L1 and Ki-67 (R=0.26, <0.001). The clinicopathologic features and laboratory parameters such as gender, smoking history, histological types, TNM stage, tumor size, ALB, and FIB were all significantly associated with PD-L1 and Ki-67 expression (all <0.05).
The expression of PD-L1 and Ki-67 is related to some clinicopathologic features and inflammatory factors, which brings new sight for exploiting combination biomarkers and therapeutic strategies.
探讨非小细胞肺癌（NSCLC）患者外周血中程序性死亡受体配体1（PD-L1）、增殖细胞核抗原（Ki-67）之间的关系，以及PD-L1、Ki-67与临床病理特征和实验室参数之间的关联。
回顾性分析213例NSCLC患者的临床记录。根据Ki-67和PD-L1的临界值将患者分为高表达组或低表达组。采用线性回归分析PD-L1和Ki-67表达的相关性。数据采用曼-惠特尼检验。采用卡方检验检测PD-L1与Ki-67的关系。
线性回归分析显示PD-L1与Ki-67的表达呈正相关（R=0.26，P<0.001）。临床病理特征和实验室参数，如性别、吸烟史、组织学类型、TNM分期、肿瘤大小、白蛋白（ALB）和纤维蛋白原（FIB）均与PD-L1和Ki-67表达显著相关（均P<0.05）。
PD-L1和Ki-67的表达与某些临床病理特征和炎症因子有关，这为开发联合生物标志物和治疗策略带来了新的视角。
