Wang Huifang, Qiu Donghai, Su Xiaojuan, Chen Li, Qin Yongtao, Li Lihong, Li Zhaodi
Department of Obstetrics and Gynecology, Quanzhou Medical College Quanzhou 362010, Fujian, China.
Maternity Nursing Teaching and Research Office, Quanzhou Medical College Quanzhou 362010, Fujian, China.
Am J Transl Res. 2023 Aug 15;15(8):5323-5330. eCollection 2023.
This study aimed to explore the value of T lymphocyte subset detection in cervical intraepithelial neoplasia (CIN).
In this retrospective analysis, T lymphocyte subsets in 186 CIN patients were detected. Venous blood T lymphocyte subsets were analyzed in patients with different CIN grades, and Spearman correlation analysis was conducted between CIN grade and T lymphocyte subsets.
(1) There were significant differences in the CD3, CD4, CD8, and CD4/CD8 levels before and 1, 2, and 3 months after treatment (<0.05). Furthermore, significant differences were found in CD3, CD4, CD8, and CD4/CD8 between every pair of time points (<0.05). (2) Comparison of human papillomavirus distribution in patients with different CIN grades showed <0.05. (3) The level of T lymphocyte subsets in the venous blood of patients with different CIN grades was compared, and significant differences were found, <0.05. Higher CIN grade was associated with lower levels of CD3, CD4 and CD4/CD8, as well as higher level of CD8. (4) Spearman analysis showed that CIN grade was negatively correlated with the levels of CD3, CD4, and CD4/CD8 (<0.05) and positively correlated with the level of CD8 (<0.05).
The levels of T lymphocyte subsets were found to be closely associated with the severity of CIN. Therefore, the detection of T lymphocyte subsets in venous blood could be a valuable clinical tool for predicting the presence and degree of CIN.
本研究旨在探讨T淋巴细胞亚群检测在宫颈上皮内瘤变（CIN）中的价值。
在这项回顾性分析中，检测了186例CIN患者的T淋巴细胞亚群。分析了不同CIN分级患者的静脉血T淋巴细胞亚群，并对CIN分级与T淋巴细胞亚群进行Spearman相关性分析。
（1）治疗前及治疗后1、2、3个月的CD3、CD4、CD8及CD4/CD8水平存在显著差异（<0.05）。此外，各时间点之间的CD3、CD4、CD8及CD4/CD8也存在显著差异（<0.05）。（2）不同CIN分级患者的人乳头瘤病毒分布比较显示差异<0.05。（3）比较不同CIN分级患者静脉血中T淋巴细胞亚群水平，发现存在显著差异，<0.05。CIN分级越高，CD3、CD4及CD4/CD8水平越低，而CD8水平越高。（4）Spearman分析显示，CIN分级与CD3、CD4及CD4/CD8水平呈负相关（<0.05），与CD8水平呈正相关（<0.05）。
发现T淋巴细胞亚群水平与CIN的严重程度密切相关。因此，检测静脉血中的T淋巴细胞亚群可能是预测CIN的存在及程度的一种有价值的临床工具。
