M Sabarinathan, Ds Deepak Rajan, N Ananthi, Krishnan Madhan
Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam - 602015, Chennai, Tamilnadu, India.
Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam-603103, Tamilnadu, India.
Bioinformation. 2022 Nov 30;18(11):1109-1113. doi: 10.6026/973206300181109. eCollection 2022.
Metabolic syndrome is a cluster of various clinical and biochemical abnormalities, needs early diagnosis and treatment to reduce morbidity and mortality. The present study is designed to compare Atherogenic Index of Plasma, Lipid Accumulation Product and Visceral Adiposity Index with metabolic syndrome components in patients with metabolic syndrome. The study comprises of 150 metabolic syndrome patients and 150 age and sex matched healthy controls of both genders in the age group of 20 - 65 years. Atherogenic Index of Plasma, lipid accumulation and Visceral Adiposity Index product index were calculated for all participants. Pearson Correlation was used to compareatherogenic Index of plasma, lipid accumulation and Visceral Adiposity Index product between cases and controls. The receiver operating characteristic curve (ROC) was used to compare the area under the ROC curve (AUC) of Atherogenic Index of Plasma, lipid accumulation and Visceral Adiposity Index product with metabolic syndrome. The comparisons between the BMI, WC, Atherogenic Index of Plasma ,lipid accumulation and Visceral Adiposity Index product were significantly higher in metabolic syndrome cases (p<0.001).Although the entire index were independently associated with Mets, AIP showed the highest area under the curve (0.954, 95% CI 0.929 0.978,p value p<0.0001) in identifying metabolic syndrome.
代谢综合征是一系列各种临床和生化异常情况,需要早期诊断和治疗以降低发病率和死亡率。本研究旨在比较血浆致动脉粥样硬化指数、脂质蓄积产物和内脏脂肪指数与代谢综合征患者的代谢综合征组分。该研究纳入了150例代谢综合征患者以及150例年龄和性别匹配的健康对照者,年龄在20至65岁之间,涵盖男女两性。为所有参与者计算血浆致动脉粥样硬化指数、脂质蓄积和内脏脂肪指数产物指数。采用Pearson相关性分析比较病例组和对照组之间的血浆致动脉粥样硬化指数、脂质蓄积和内脏脂肪指数产物。采用受试者工作特征曲线(ROC)比较血浆致动脉粥样硬化指数、脂质蓄积和内脏脂肪指数产物与代谢综合征的ROC曲线下面积(AUC)。代谢综合征病例组的体重指数、腰围、血浆致动脉粥样硬化指数、脂质蓄积和内脏脂肪指数产物之间的比较显著更高(p<0.001)。尽管所有指标均与代谢综合征独立相关,但在识别代谢综合征方面,AIP显示出最高的曲线下面积(0.954,95%CI 0.929至0.978,p值p<0.0001)。