Department of Psychiatry, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC.
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, 2F, No. 325, Sec. 2, Cheng-Gong Rd., Neihu district, Taipei City, 114, Taiwan, ROC.
Sci Rep. 2021 May 10;11(1):9900. doi: 10.1038/s41598-021-89307-z.
Deeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) has been well established. We conducted a 9-year longitudinal study to identify the association between easily measured lipid parameters, future MetS, hypertension and T2DM by gender and age distribution. Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medical inspection at Tri-Service General Hospital (TSGH) in Taiwan, had been enrolled in this study. Atherogenic index of plasma (AIP) was a logarithmically transformed ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C). Through multivariate regression analyses, the hazard ratio (HR) of AIP for MetS, hypertension and T2DM were illustrated. AIP revealed significant association with all the aforementioned diseases through the entire three models for both genders. Additionally, AIP revealed significant correlation which remained still after fully adjustment in MetS, hypertension, and T2DM groups for subjects aged 40-64-year-old. Nevertheless, for participants aged above 65-year-old, AIP only demonstrated significant association in MetS group. Our results explore the promising value of AIP to determine the high-risk subjects, especially meddle-aged ones, having MetS, hypertension, and T2DM in the present and the future.
高脂血症相关性强，心血管疾病自 20 世纪初起成为当代世界致死首要病因。其与代谢综合征（MetS）、高血压和 2 型糖尿病（T2DM）的相关性已得到充分证实。我们开展了一项为期 9 年的纵向研究，旨在按性别和年龄分布，确定易于测量的血脂参数与未来 MetS、高血压和 T2DM 之间的关联。研究纳入了台湾三军总医院（TSGH）接受标准体检的 7670 名参与者，他们按年龄（青年组：<40 岁、中年组：≥40 岁且<65 岁和老年组：≥65 岁）分为三组。载脂蛋白（Apo）为甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）的对数转换比值。通过多变量回归分析，展示了 Apo 对 MetS、高血压和 T2DM 的风险比（HR）。Apo 与上述所有疾病在所有三个模型中均存在显著相关性，且无论男女均如此。此外，在 40-64 岁的受试者中，Apo 在 MetS、高血压和 T2DM 组中经过充分调整后仍具有显著相关性。然而，对于年龄在 65 岁以上的参与者，Apo 仅在 MetS 组中具有显著相关性。我们的研究结果表明，Apo 具有潜在价值，可用于确定未来患有 MetS、高血压和 T2DM 的高危人群，尤其是中年人群。
