Wang Zhi-Ning, Xu Tao, Liu Kang-Sheng
Department of Oncology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University Nanjing, Jiangsu Province, China.
Xi'an Jiaotong University Global Health Institute Xi'an 710049, Shaanxi, China.
Am J Cancer Res. 2023 Aug 15;13(8):3315-3323. eCollection 2023.
Th22 cells are a newly identified subpopulation of CD4 T lymphocytes distinct from Th1, Th2, and Th17 cells, which secretes mainly interleukin-22 (IL-22), in addition to a variety of other cytokines. The function of Th22 cells in tumors is mainly realized through IL-22, which can activate JAK/STAT and MAPK cell signaling pathways, thereby regulating the anti-tumor immune response of the body. The main function of Th22 cells is to participate in mucosal defense, tissue repair, and wound healing. However, controversial data have shown that overexpression of IL-22 can lead to pathological changes under inflammatory conditions and tumor progression. In this review, we searched the PubMed and Web of Science databases for articles and reviews published before May 6, 2022, using the keywords "Th22 cells, T helper 22 cells, cancer, tumor", and conducted a comprehensive review of the relevant literature. In addition, this article offers an overview of the relevant findings on the function of Th22 cells in tumors published in recent years, along with a more comprehensive analysis of the functions and mechanisms of Th22 cells in tumors. This article will hopefully inspire new future directions in the research on cancer therapy.
Th22细胞是一种新发现的CD4 T淋巴细胞亚群，不同于Th1、Th2和Th17细胞，它主要分泌白细胞介素-22（IL-22），此外还分泌多种其他细胞因子。Th22细胞在肿瘤中的功能主要通过IL-22实现，IL-22可激活JAK/STAT和MAPK细胞信号通路，从而调节机体的抗肿瘤免疫反应。Th22细胞的主要功能是参与黏膜防御、组织修复和伤口愈合。然而，有争议的数据表明，IL-22的过度表达在炎症条件下可导致病理变化和肿瘤进展。在本综述中，我们使用关键词“Th22细胞、辅助性T细胞22、癌症、肿瘤”在PubMed和Web of Science数据库中检索了2022年5月6日前发表的文章和综述，并对相关文献进行了全面综述。此外，本文概述了近年来发表的关于Th22细胞在肿瘤中功能的相关研究结果，并对Th22细胞在肿瘤中的功能和机制进行了更全面的分析。本文有望为癌症治疗研究激发新的未来方向。
