Zheng Yue, Li Tong
a Cardiology , The Third Central Clinical College of Tianjin Medical University , Tianjin , China.
b Cardiology , Tianjin Key Laboratory of Artificial Cell.
Hum Vaccin Immunother. 2018;14(12):2811-2819. doi: 10.1080/21645515.2018.1509649. Epub 2018 Oct 31.
Interleukin -22 (IL-22) is a member of interleukin-10 (IL-10) family cytokines that is produced by different types of lymphocytes included in both innate and adaptive immune systems. These lymphocytes include activated T cells, most notably Th17 and Th22 cells, as well as NK cells, γδ T cells, etc. IL-22 mediate its effects via the IL-22-IL-22R complex and subsequent Janus Kinase-signal transduces and activators transcription (JAK-STAT) signaling pathway. According to recent evidence, IL-22 played a critical role in the pathogenesis of many non-autoimmune diseases. In this review, we mainly discussed the recent findings and advancements of the role of IL-22 in several non-autoimmune diseases, such as acute lung injury, atherosclerosis and some bacterial infections, suggesting that IL-22 may have therapeutic potential for treating non-autoimmune diseases.
白细胞介素-22（IL-22）是白细胞介素-10（IL-10）家族细胞因子的成员，由先天免疫系统和适应性免疫系统中的不同类型淋巴细胞产生。这些淋巴细胞包括活化的T细胞，最显著的是Th17和Th22细胞，以及自然杀伤细胞、γδT细胞等。IL-22通过IL-22-IL-22R复合物以及随后的Janus激酶-信号转导和转录激活因子（JAK-STAT）信号通路介导其作用。根据最近的证据，IL-22在许多非自身免疫性疾病的发病机制中起关键作用。在本综述中，我们主要讨论了IL-22在几种非自身免疫性疾病（如急性肺损伤、动脉粥样硬化和一些细菌感染）中的作用的最新发现和进展，表明IL-22可能具有治疗非自身免疫性疾病的潜力。
