Puttaraju Mahesh Kagarae, Nitin Priyanka
Department of Oral Medicine and Radiology, JSS Dental College & Hospital, JSS Academy of Higher Education & Research Mysuru 570015, Karnataka, India.
Department of Oral Pathology and Microbiology, JSS Dental College & Hospital, JSS Academy of Higher Education & Research Mysuru 570015, Karnataka, India.
Am J Cancer Res. 2023 Aug 15;13(8):3650-3658. eCollection 2023.
Oral cancer was and still is an underestimated disease in terms of incidence and mortality rates. As a result, requires early detection and urgent prevention. This article describes a framework that covers the significant stages of conceptual development of oral cancer. Conceptual model is useful in understanding the pathogenesis and understand the disease processes. This article signifies information on various aspects of perspective risk and the role played by it. Article covers the following aspects: what are the perspective risks, what changes it causes to normal cell, what are the direct and indirect effects on normal cell, cellular changes seen with normal cell when affected with perspective risk, transformation of normal cell to oral potentially malignant disorders (OPMD) and changes seen during transformation into cancer. Understanding the conceptual model of oral cancer transformation will be a paradigm shift in future research in the field and early management of oral cancer, which will reduce the disease burden on the nation.
无论在过去还是现在，口腔癌在发病率和死亡率方面都是一种被低估的疾病。因此，需要早期检测和紧急预防。本文描述了一个涵盖口腔癌概念发展重要阶段的框架。概念模型有助于理解发病机制和疾病过程。本文阐述了关于潜在风险各个方面及其所起作用的信息。文章涵盖以下方面：什么是潜在风险，它会使正常细胞发生哪些变化，对正常细胞的直接和间接影响是什么，正常细胞受到潜在风险影响时出现的细胞变化，正常细胞向口腔潜在恶性病变（OPMD）的转变以及转变为癌症过程中出现的变化。了解口腔癌转变的概念模型将是该领域未来研究以及口腔癌早期管理的范式转变，这将减轻国家的疾病负担。
