非洲女性的良性乳腺疾病与乳腺癌风险：一项病例对照研究。

Benign breast disease and breast cancer risk in African women: A case-control study.

作者信息

Omoleye Olasubomi J, Freeman Jincong Q, Oluwasanu Mojisola, Adeniji-Sofoluwe Adenike, Woodard Anna E, Aribisala Benjamin S, Adejumo Prisca O, Ntekim Atara, Makumbi Timothy, Ndom Paul, Ajayi IkeOluwapo O, Olopade Olufunmilayo I, Huo Dezheng

机构信息

University of Chicago.

University of Ibadan.

出版信息

Res Sq. 2023 Sep 1:rs.3.rs-3301977. doi: 10.21203/rs.3.rs-3301977/v1.

DOI:10.21203/rs.3.rs-3301977/v1

PMID:37693385

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10491333/

Abstract

PURPOSE

To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women.

METHODS

BC cases and matched controls were enrolled in three sub-Saharan African countries, Nigeria Cameroon, and Uganda, between 1998-2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD.

RESULTS

Of 6418 participants, 55.7% (3572) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] = 1.47, 95% CI: 1.13-1.91). Biopsy-confirmed BBD was associated with BC (aOR = 3.11, 95% CI: 1.78-5.44). BBD did not significantly mediate the effects of any of the selected BC risk factors.

CONCLUSIONS

In this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.

摘要

目的

在非洲女性的异质人群中研究良性乳腺疾病（BBD）与乳腺癌（BC）之间的关联。

方法

1998年至2018年期间，在撒哈拉以南非洲的三个国家（尼日利亚、喀麦隆和乌干达）招募了乳腺癌病例和匹配的对照。采用多变量逻辑回归来检验BBD与BC之间的关联。选择与BBD和BC双重相关的风险因素。使用参数中介分析模型，我们评估了所选的BC风险因素是否由BBD介导。

结果

在6418名参与者中，55.7%（3572名）为乳腺癌病例。360名（5.7%）自我报告有BBD。纤维腺瘤（46.8%）是报告最多的BBD。自我报告有BBD病史的女性患BC的几率高于没有的女性（调整后的优势比[aOR]=1.47，95%置信区间：1.13-1.91）。活检确诊的BBD与BC相关（aOR=3.11，95%置信区间：1.78-5.44）。BBD并未显著介导任何所选BC风险因素的作用。