Dorjgochoo Tsogzolmaa, Deming Sandra L, Gao Yu-Tang, Lu Wei, Zheng Ying, Ruan Zhixian, Zheng Wei, Shu Xiao Ou
Department of Medicine, Vanderbilt Epidemiology Center, Institute of Medicine & Public Health, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Sixth Floor, Suite 600, 2525 West End Avenue, Nashville, TN 37203-1738, USA.
Cancer Causes Control. 2008 Oct;19(8):819-28. doi: 10.1007/s10552-008-9145-6. Epub 2008 Mar 18.
Data from the Shanghai Breast Cancer Study were analyzed to evaluate the relationship between benign breast disease (BBD) and breast cancer among Chinese women with a self-report of physician-diagnosed BBD.
Study participants consisted of 3,452 breast cancer cases and 3,474 population controls recruited by the Shanghai Breast Cancer Study. In-person interviews were conducted to collect information on demographics and suspected risk factors for breast cancer, including a detailed history of BBD. Unconditional logistic regression was used to derive adjusted odds ratios (OR(adj)) and 95% confidence intervals (CI) for the association between self-reported BBD and breast cancer.
Women with breast cancer were significantly more likely to have a self-reported history of BBD including lobular proliferation (OR(adj) = 1.6; 95% CI 1.4-1.8), fibroadenoma (OR(adj) = 1.9; 95% CI 1.6-2.3), and other BBD (OR(adj) = 1.6; 95% CI 1.3-2.1). Breast cancer risk was lower for surgically treated fibroadenoma as compared to non-surgically treated and higher for other BBDs that were surgically treated versus non-surgically treated.
Our results suggest that personal history of BBD is associated with an increased risk of future breast cancer among women in China. Surgical intervention for fibroadenoma may reduce the risk.
对上海乳腺癌研究的数据进行分析，以评估在中国女性中，自我报告有医生诊断的良性乳腺疾病（BBD）与乳腺癌之间的关系。
研究参与者包括上海乳腺癌研究招募的3452例乳腺癌病例和3474名人群对照。进行了面对面访谈，以收集有关人口统计学和乳腺癌疑似危险因素的信息，包括详细的BBD病史。使用无条件逻辑回归来得出自我报告的BBD与乳腺癌之间关联的调整比值比（OR(adj)）和95%置信区间（CI）。
患有乳腺癌的女性更有可能有自我报告的BBD病史，包括小叶增生（OR(adj)=1.6；95%CI 1.4-1.8）、纤维腺瘤（OR(adj)=1.9；95%CI 1.6-2.3）和其他BBD（OR(adj)=1.6；95%CI 1.3-2.1）。与未手术治疗的纤维腺瘤相比，手术治疗的纤维腺瘤患乳腺癌的风险较低；与未手术治疗的其他BBD相比，手术治疗的其他BBD患乳腺癌的风险较高。
我们的结果表明，BBD个人病史与中国女性未来患乳腺癌的风险增加有关。对纤维腺瘤进行手术干预可能会降低风险。
