回避限制型食物摄入障碍的基因与环境（ARFID-GEN）：研究方案。

Arfid Genes and Environment (ARFID-GEN): Study Protocol.

作者信息

Bulik Cynthia M, Micali Nadia, MacDermod Casey M, Qi Baiyu, Munn-Chernoff Melissa A, Thornton Laura M, White Jennifer, Dinkler Lisa, Pisetsky Emily M, Johnson Jessica, Devine Katelin R, Ortiz Shelby N, Silverman Ava E, Berthold Natasha, Dumain Alexis, Guintivano Jerry, Halvorsen Matthew, James J

机构信息

University of North Carolina at Chapel Hill.

Mental Health Services of the Capital Region of Denmark.

出版信息

Res Sq. 2023 Aug 31:rs.3.rs-3186174. doi: 10.21203/rs.3.rs-3186174/v1.

DOI:10.21203/rs.3.rs-3186174/v1

PMID:37693386

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10491341/

Abstract

BACKGROUND

The Avoidant Restrictive Food Intake Disorder Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults.

METHODS

A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18+) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted.

DISCUSSION

ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver "actionable" findings that can be transformed into clinically meaningful insights.

TRIAL REGISTRATION

ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.

摘要

背景

回避型限制性食物摄入障碍的基因与环境（ARFID-GEN）研究旨在探究导致儿童和成人患ARFID风险的遗传和环境因素。

方法

将纳入来自美国的总共3000名患有ARFID的儿童和成人。患有ARFID的父母/监护人及其子女（7至17岁）和成人（18岁及以上）将完成全面的在线同意书、父母对儿童同意的核实（如适用）以及表型分析。已登记的患有ARFID的参与者将提交唾液样本进行基因分型。将开展一项关于ARFID的全基因组关联研究。