进食障碍遗传学倡议（EDGI）：研究方案。
The Eating Disorders Genetics Initiative (EDGI): study protocol.
机构信息
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77, Stockholm, Sweden.
出版信息
BMC Psychiatry. 2021 May 4;21(1):234. doi: 10.1186/s12888-021-03212-3.
BACKGROUND
The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.
METHODS
A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).
DISCUSSION
EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights.
TRIAL REGISTRATION
EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 .
背景
进食障碍遗传学倡议 (EDGI) 是一项国际研究，旨在探索基因和环境在神经性厌食症、神经性贪食症和暴食障碍中的作用。
方法
该研究将从美国、澳大利亚、新西兰和丹麦共纳入 14500 名进食障碍患者和 1500 名对照。在美国、澳大利亚和新西兰，参与者将完成全面的在线表型分析，并提交唾液样本进行基因分型。在丹麦，将通过国家患者登记处识别进食障碍患者，并使用出生时存档的血斑进行基因分型。EDGI 将进行全基因组关联研究，并通过与精神疾病基因组学联盟进食障碍工作组（PGC-ED）的其他数据进行荟萃分析。
讨论
EDGI 代表了迄今为止进行的最大规模的进食障碍遗传学研究，旨在快速推进对三种主要进食障碍（神经性厌食症、神经性贪食症和暴食障碍）的遗传学研究。我们将阐明进食障碍之间以及与其他精神和代谢障碍和特征之间的遗传结构。我们的目标是使 EDGI 提供可以转化为具有临床意义的见解的“可操作”发现。
注册
EDGI 是一项已注册的临床试验：clinicaltrials.gov NCT04378101。
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