Amorim Edilberto, Zheng Wei-Long, Ghassemi Mohammad M, Aghaeeaval Mahsa, Kandhare Pravinkumar, Karukonda Vishnu, Lee Jong Woo, Herman Susan T, Sivaraju Adithya, Gaspard Nicolas, Hofmeijer Jeannette, van Putten Michel J A M, Sameni Reza, Reyna Matthew A, Clifford Gari D, Westover M Brandon
Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
medRxiv. 2023 Aug 28:2023.08.28.23294672. doi: 10.1101/2023.08.28.23294672.
To develop a harmonized multicenter clinical and electroencephalography (EEG) database for acute hypoxic-ischemic brain injury research involving patients with cardiac arrest.
Multicenter cohort, partly prospective and partly retrospective.
Seven academic or teaching hospitals from the U.S. and Europe.
Individuals aged 16 or older who were comatose after return of spontaneous circulation following a cardiac arrest who had continuous EEG monitoring were included.
not applicable.
Clinical and EEG data were harmonized and stored in a common Waveform Database (WFDB)-compatible format. Automated spike frequency, background continuity, and artifact detection on EEG were calculated with 10 second resolution and summarized hourly. Neurological outcome was determined at 3-6 months using the best Cerebral Performance Category (CPC) scale. This database includes clinical and 56,676 hours (3.9 TB) of continuous EEG data for 1,020 patients. Most patients died (N=603, 59%), 48 (5%) had severe neurological disability (CPC 3 or 4), and 369 (36%) had good functional recovery (CPC 1-2). There is significant variability in mean EEG recording duration depending on the neurological outcome (range 53-102h for CPC 1 and CPC 4, respectively). Epileptiform activity averaging 1 Hz or more in frequency for at least one hour was seen in 258 (25%) patients (19% for CPC 1-2 and 29% for CPC 3-5). Burst suppression was observed for at least one hour in 207 (56%) and 635 (97%) patients with CPC 1-2 and CPC 3-5, respectively.
The International Cardiac Arrest Research (I-CARE) consortium database provides a comprehensive real-world clinical and EEG dataset for neurophysiology research of comatose patients after cardiac arrest. This dataset covers the spectrum of abnormal EEG patterns after cardiac arrest, including epileptiform patterns and those in the ictal-interictal continuum.
建立一个统一的多中心临床和脑电图（EEG）数据库，用于涉及心脏骤停患者的急性缺氧缺血性脑损伤研究。
多中心队列研究，部分为前瞻性，部分为回顾性。
来自美国和欧洲的七家学术或教学医院。
纳入年龄在16岁及以上、心脏骤停后自主循环恢复后昏迷且接受连续脑电图监测的个体。
不适用。
临床和脑电图数据进行了统一，并以通用的与波形数据库（WFDB）兼容的格式存储。脑电图的自动棘波频率、背景连续性和伪迹检测以10秒分辨率计算，并每小时汇总一次。使用最佳脑功能状态分类（CPC）量表在3至6个月时确定神经功能结局。该数据库包括1020例患者的临床数据和56676小时（3.9TB）的连续脑电图数据。大多数患者死亡（n = 603，59%），48例（5%）有严重神经功能残疾（CPC 3或4），369例（36%）功能恢复良好（CPC 1 - 2）。根据神经功能结局，平均脑电图记录时长存在显著差异（CPC 1和CPC 4分别为53 - 102小时）。258例（25%）患者出现频率平均为1Hz或更高且持续至少1小时的癫痫样活动（CPC 1 - 2为19%，CPC 3 - 5为29%）。分别在207例（56%）CPC 1 - 2患者和635例（97%）CPC 3 - 5患者中观察到至少1小时的爆发抑制。
国际心脏骤停研究（I - CARE）联盟数据库为心脏骤停后昏迷患者的神经生理学研究提供了一个全面的真实世界临床和脑电图数据集。该数据集涵盖了心脏骤停后脑电图异常模式的范围，包括癫痫样模式和发作 - 发作间期连续体中的模式。
