Kantelip J P, Trolese J F, Cadilhac M, Pechadre J C, Duchêne-Marullaz P
Clin Pharmacol Ther. 1986 Nov;40(5):554-60. doi: 10.1038/clpt.1986.223.
The effects of sotalol dosing, 160, 240, and 320 mg/day, for 10 days in seven healthy volunteers were studied. Twenty-four-hour ECG was recorded continuously under placebo and on days 2, 4, 6, 8, 10, 11, 13, and 14. Sotalol at the three doses significantly lowered mean heart rate, reducing mean diurnal heart rate significantly between noon and 6:00 PM and decreasing mean nocturnal heart rate between midnight and 6:00 AM at 320 mg/day. Although there was no change in plasma sotalol between days 4 and 10, at high doses a significant decrease in bradycardiac effect occurred. PR intervals and QTc intervals were lengthened at all doses during the daytime. At the highest dose, the PR interval was lengthened during the nighttime.
研究了索他洛尔剂量分别为160、240和320mg/天，连续10天对7名健康志愿者的影响。在服用安慰剂期间以及第2、4、6、8、10、11、13和14天连续记录24小时心电图。三个剂量的索他洛尔均显著降低平均心率，在320mg/天剂量下，显著降低中午至下午6点之间的平均日间心率，并降低午夜至凌晨6点之间的平均夜间心率。虽然第4天至第10天血浆索他洛尔水平没有变化，但高剂量时心动过缓效应显著降低。白天所有剂量下PR间期和QTc间期均延长。在最高剂量时，夜间PR间期延长。
