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正常志愿者静脉注射后（+）-索他洛尔与（±）-索他洛尔心血管效应的比较。

A comparison of the cardiovascular effects of (+)-sotalol and (+/-)-sotalol following intravenous administration in normal volunteers.

作者信息

Johnston G D, Finch M B, McNeill J A, Shanks R G

出版信息

Br J Clin Pharmacol. 1985 Nov;20(5):507-10. doi: 10.1111/j.1365-2125.1985.tb05109.x.

DOI:10.1111/j.1365-2125.1985.tb05109.x
PMID:4074623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1400709/
Abstract

In a placebo controlled open study in six healthy male volunteers (+)-sotalol in the dose range 0.125 mg kg-1-2.0 mg kg-1 intravenously, was found to have little or no beta-adrenoceptor blocking activity in comparison to the racemic mixture (+/-)-sotalol. The repolarization effects of (+)- and (+/-)-sotalol on the QTc interval however were comparable over the same dose range. The beta-adrenoceptor blocking activity and repolarization effects of sotalol appear to be unrelated.

摘要

在一项针对6名健康男性志愿者的安慰剂对照开放研究中，静脉注射剂量范围为0.125毫克/千克至2.0毫克/千克的（+）-索他洛尔，与消旋混合物（+/-）-索他洛尔相比，几乎没有或没有β-肾上腺素能受体阻断活性。然而，在相同剂量范围内，（+）-和（+/-）-索他洛尔对QTc间期的复极作用相当。索他洛尔的β-肾上腺素能受体阻断活性和复极作用似乎没有关联。

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1
A comparison of the cardiovascular effects of (+)-sotalol and (+/-)-sotalol following intravenous administration in normal volunteers.正常志愿者静脉注射后（+）-索他洛尔与（±）-索他洛尔心血管效应的比较。
Br J Clin Pharmacol. 1985 Nov;20(5):507-10. doi: 10.1111/j.1365-2125.1985.tb05109.x.
2
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Br J Clin Pharmacol. 1990 Aug;30(2):195-202. doi: 10.1111/j.1365-2125.1990.tb03765.x.
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[Plasma level and action of sotalol-HCL on the ECG interval after parenteral administration in healthy subjects].[健康受试者静脉注射盐酸索他洛尔后血浆水平及对心电图间期的作用]
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[Comparative beta-adrenoceptor blocking effects and pharmacokinetics of sotalol and propranolol in healthy volunteers].[索他洛尔与普萘洛尔在健康志愿者中的β-肾上腺素受体阻断作用及药代动力学比较]
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Effects of sotalol on ambulatory electrocardiography in volunteers.索他洛尔对志愿者动态心电图的影响。
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[Comparison of the hemodynamics effects of D-sotalol and D,L-sotalol].[D-索他洛尔与消旋索他洛尔血流动力学效应的比较]
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A mechanism of D-(+)-sotalol effects on heart rate not related to beta-adrenoceptor antagonism.D-(+)-索他洛尔对心率的影响机制与β-肾上腺素能受体拮抗作用无关。
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6
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Naunyn Schmiedebergs Arch Pharmacol. 1990 Mar;341(3):215-20. doi: 10.1007/BF00169733.

本文引用的文献

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Fluorometric high-performance liquid chromatographic determination of sotalol in biological fluids.
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Br Heart J. 1982 Jun;47(6):521-6. doi: 10.1136/hrt.47.6.521.
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Effects of the beta-adrenoceptor-blocking agent Sotalol on ventricular arrhythmias in patients with chronic ischemic heart disease. A placebo-controlled, double-blind cross-over study.β-肾上腺素能受体阻滞剂索他洛尔对慢性缺血性心脏病患者室性心律失常的影响。一项安慰剂对照、双盲交叉研究。
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Electrophysiologial and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue.MJ 1999对犬和兔心脏组织的电生理及β受体阻断作用。
Circ Res. 1970 Jun;26(6):661-78. doi: 10.1161/01.res.26.6.661.
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A random-zero sphygmomanometer.随机零位血压计。
Lancet. 1970 Feb 14;1(7642):337-8. doi: 10.1016/s0140-6736(70)90709-9.