A comparison of the cardiovascular effects of (+)-sotalol and (+/-)-sotalol following intravenous administration in normal volunteers.
作者信息
Johnston G D, Finch M B, McNeill J A, Shanks R G
出版信息
Br J Clin Pharmacol. 1985 Nov;20(5):507-10. doi: 10.1111/j.1365-2125.1985.tb05109.x.
Abstract
In a placebo controlled open study in six healthy male volunteers (+)-sotalol in the dose range 0.125 mg kg-1-2.0 mg kg-1 intravenously, was found to have little or no beta-adrenoceptor blocking activity in comparison to the racemic mixture (+/-)-sotalol. The repolarization effects of (+)- and (+/-)-sotalol on the QTc interval however were comparable over the same dose range. The beta-adrenoceptor blocking activity and repolarization effects of sotalol appear to be unrelated.
摘要
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