正常志愿者静脉注射后（+）-索他洛尔与（±）-索他洛尔心血管效应的比较。
A comparison of the cardiovascular effects of (+)-sotalol and (+/-)-sotalol following intravenous administration in normal volunteers.
作者信息
Johnston G D, Finch M B, McNeill J A, Shanks R G
出版信息
Br J Clin Pharmacol. 1985 Nov;20(5):507-10. doi: 10.1111/j.1365-2125.1985.tb05109.x.
Abstract
In a placebo controlled open study in six healthy male volunteers (+)-sotalol in the dose range 0.125 mg kg-1-2.0 mg kg-1 intravenously, was found to have little or no beta-adrenoceptor blocking activity in comparison to the racemic mixture (+/-)-sotalol. The repolarization effects of (+)- and (+/-)-sotalol on the QTc interval however were comparable over the same dose range. The beta-adrenoceptor blocking activity and repolarization effects of sotalol appear to be unrelated.
摘要
在一项针对6名健康男性志愿者的安慰剂对照开放研究中，静脉注射剂量范围为0.125毫克/千克至2.0毫克/千克的（+）-索他洛尔，与消旋混合物（+/-）-索他洛尔相比，几乎没有或没有β-肾上腺素能受体阻断活性。然而，在相同剂量范围内，（+）-和（+/-）-索他洛尔对QTc间期的复极作用相当。索他洛尔的β-肾上腺素能受体阻断活性和复极作用似乎没有关联。
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