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骨盆褥疮治疗及其结果的回顾性分析。

Retrospective analysis of the management of pelvic decubitus ulcers and their outcomes.

作者信息

Damioli Laura, Shepard Zachary, Wilson Melissa P, Erlandson Kristine M

机构信息

Infectious Disease Division, University of Colorado Hospital, 12700 E. 19th Avenue B-168, Research Complex 2 Building, Aurora, CO 80045, USA.

Division of Infectious Diseases, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.

出版信息

Ther Adv Infect Dis. 2023 Sep 6;10:20499361231196664. doi: 10.1177/20499361231196664. eCollection 2023 Jan-Dec.

Abstract

BACKGROUND

Many patients with decubitus-related osteomyelitis are ineligible for myocutaneous flapping, and optimal management in this population is unknown. We describe treatments and outcomes of hospitalized patients with decubitus ulcer-related osteomyelitis who did not undergo surgical reconstruction or coverage.

METHODS

We systematically identified hospitalized patients with diagnoses of pelvic, sacral, or femoral osteomyelitis due to decubitus ulceration between 1 January 2018 and 31 December 2018. Demographics, comorbidities, laboratory data, and outcomes were collected by manual chart review. T-tests or Chi-square tests were used for descriptive statistical comparisons; logistic regressions were used to explore the odds of readmission, osteomyelitis-related readmission, and death.

RESULTS

Of 89 patients meeting inclusion criteria, 34 (38%) received surgical debridement and ⩾6 weeks of antibiotics; 55 (62%) received either antibiotics alone or debridement and <6 weeks of antibiotics. Mean age was 55 (standard deviation 18) years, 55% of patients were male, and 69% had spinal cord injury or other form of paralysis. Within 1 year, 56 (63%) patients were readmitted, 38 (44%) patients were readmitted due to complications from osteomyelitis, and 15 (17%) died. We found no significant differences in readmission (OR = 1.33, 95% CI: 0.54-3.21,  = 0.53), readmission related to osteomyelitis (OR = 1.64, 95% CI: 0.69-4.04,  = 0.27), subsequent sepsis (OR = 2.27, 95% CI: 0.83-6.93,  = 0.13), or death (OR = 2.88, 95% CI: 0.83-13.4,  = 0.12) by treatment group.

CONCLUSIONS

Among patients with decubitus-related osteomyelitis who did not undergo myocutaneous flapping, outcomes were generally poor regardless of treatment, and not significantly improved with prolonged antibiotics. Prospective studies are needed to assess best practice strategies for this challenging patient population.

摘要

背景

许多患有褥疮相关骨髓炎的患者不适合进行肌皮瓣转移术,而该人群的最佳治疗方案尚不清楚。我们描述了未接受手术重建或覆盖治疗的褥疮溃疡相关骨髓炎住院患者的治疗方法及结果。

方法

我们系统地识别了2018年1月1日至2018年12月31日期间因褥疮溃疡诊断为骨盆、骶骨或股骨骨髓炎的住院患者。通过人工查阅病历收集人口统计学、合并症、实验室数据及结果。采用t检验或卡方检验进行描述性统计比较;采用逻辑回归分析探索再入院、骨髓炎相关再入院及死亡的几率。

结果

89例符合纳入标准的患者中,34例(38%)接受了手术清创及至少6周的抗生素治疗;55例(62%)仅接受了抗生素治疗或清创及少于6周的抗生素治疗。平均年龄为55岁(标准差18),55%的患者为男性,69%的患者患有脊髓损伤或其他形式的瘫痪。1年内,56例(63%)患者再次入院,38例(44%)患者因骨髓炎并发症再次入院,15例(17%)患者死亡。我们发现治疗组在再入院(比值比=1.33,95%置信区间:0.54-3.21,P=0.53)、骨髓炎相关再入院(比值比=1.64,95%置信区间:0.69-4.04,P=0.27)、随后的脓毒症(比值比=2.27,95%置信区间:0.83-6.93,P=0.13)或死亡(比值比=2.88,95%置信区间:0.83-13.4,P=0.12)方面无显著差异。

结论

在未进行肌皮瓣转移术的褥疮相关骨髓炎患者中,无论采用何种治疗方法,预后通常较差,延长抗生素治疗时间也未显著改善预后。需要进行前瞻性研究以评估针对这一具有挑战性患者群体的最佳治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8e3/10483971/1a2ea64e70f0/10.1177_20499361231196664-fig1.jpg

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