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骨盆骨骨髓炎:一种多学科治疗方法

Osteomyelitis of the Pelvic Bones: A Multidisciplinary Approach to Treatment.

作者信息

Dudareva Maria, Ferguson Jamie, Riley Nicholas, Stubbs David, Atkins Bridget, McNally Martin

机构信息

The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, OX3 7LD, United Kingdom.

出版信息

J Bone Jt Infect. 2017 Oct 9;2(4):184-193. doi: 10.7150/jbji.21692. eCollection 2017.

Abstract

A case series review of chronic pelvic osteomyelitis treated with combined medical and surgical treatment by a multidisciplinary team. All patients treated with surgical excision of pelvic osteomyelitis at our tertiary referral centre between 2002 and 2014 were included. All received combined care from a clinical microbiologist, an orthopaedic surgeon and a plastic surgeon. The rate of recurrent infection, wound healing problems and post-operative mortality was determined in all. Treatment failure was defined as reoperation involving further bone debridement, a requirement for the use of long-term suppressive antibiotics or sinus recurrence. Sixty-one adults (mean age 50.2 years, range 16.8-80.6) underwent surgery. According to the Cierny-Mader classification of osteomyelitis there were 19 type II, 35 type III and 7 type IV cases. The ischium was the most common site of infection. Osteomyelitis was usually the result of contiguous focus infection associated with decubitus ulcers, predominantly in patients with spinal or cerebral disorders. Most patients with positive microbiology had polymicrobial infection (52.5%). Thirty patients required soft tissue reconstruction with muscle or myocutaneous flaps. Twelve deaths occurred a mean of 2.8 years following surgery (range 7 days-7.4 years). Excluding these deaths the mean follow-up was 4.6 years (range 1.5-12.2 years). Recurrent infection occurred in seven (11.5%) a mean of 1.5 years post-operatively (92 days - 5.3 years). After further treatment 58 cases (95.1%) were infection free at final follow-up. Patients in this series have many comorbidities and risk factors for poor surgical outcome. Nevertheless, the multidisciplinary approach allows successful treatment in the majority of cases.

摘要

多学科团队联合药物与手术治疗慢性盆腔骨髓炎的病例系列回顾。纳入了2002年至2014年在我们的三级转诊中心接受盆腔骨髓炎手术切除治疗的所有患者。所有患者均接受了临床微生物学家、骨科医生和整形外科医生的联合治疗。确定了所有患者的感染复发率、伤口愈合问题和术后死亡率。治疗失败定义为再次手术,包括进一步的骨清创、需要使用长期抑制性抗生素或窦道复发。61名成年人(平均年龄50.2岁,范围16.8 - 80.6岁)接受了手术。根据骨髓炎的Cierny - Mader分类,有19例II型、35例III型和7例IV型病例。坐骨是最常见的感染部位。骨髓炎通常是与褥疮相关的邻近病灶感染的结果,主要发生在患有脊柱或脑部疾病的患者中。大多数微生物学检查呈阳性的患者有混合菌感染(52.5%)。30名患者需要用肌肉或肌皮瓣进行软组织重建。12例患者在术后平均2.8年(范围7天 - 7.4年)死亡。排除这些死亡病例后,平均随访时间为4.6年(范围1.5 - 12.2年)。7例(11.5%)患者在术后平均1.5年(92天 - 5.3年)出现感染复发。经过进一步治疗,58例(95.1%)患者在最终随访时无感染。该系列中的患者有许多合并症和手术预后不良的风险因素。尽管如此,多学科方法在大多数病例中仍能实现成功治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3109/5671931/84920ee38aa7/jbjiv02p0184g001.jpg

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