接受和未接受新辅助化疗的口腔癌术后并发症比较
Comparison of Post-Operative Complications in Oral Cancer Treated with and without Neoadjuvant Chemotherapy.
作者信息
Sarma Mridul Kumar, Missong Ajit K, Sharma Moitrayee, Debnath Asim, Mahanta Neelakshi, Choudhury Mrinmoy M
机构信息
Department of Head and Neck Oncology, State Cancer Institute, Guwahati Medical College, Assam, India.
Department of Medical Oncology, State Cancer Institute, Guwahati Medical College, Assam, India.
出版信息
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1116-S1118. doi: 10.4103/jpbs.jpbs_196_23. Epub 2023 Jul 11.
AIM
The aim of the present study was to compare the treatment outcome in oral cancer cases treated with neoadjuvant chemotherapy (NACT) and upfront surgery in localized advance disease.
MATERIALS AND METHODS
A randomized, prospective study was conducted in 20 cases. Patients were divided into two groups. Group A was taken up for upfront surgery and group B was taken up for surgery after two to three cycles of NACT based on patients' response, performance, and compliance.
RESULTS
Neither group showed statistically significant differences in clinical characteristics. In the present study, satisfactory outcomes were seen in nine patients belonging to NACT group and eight patients of non-NACT group had satisfactory outcomes after surgery, which were found to be statistically significant ( = 0.001).
CONCLUSION
NACT may be considered as a treatment option for oral squamous cell carcinoma patients, particularly those with locally advanced tumors. Further prospective studies are needed to validate these findings in patients.
目的
本研究旨在比较局部晚期疾病患者接受新辅助化疗（NACT）和直接手术治疗口腔癌的疗效。
材料与方法
对20例患者进行了一项随机、前瞻性研究。患者分为两组。A组接受直接手术，B组根据患者的反应、身体状况和依从性在两到三个周期的NACT后接受手术。
结果
两组在临床特征上均未显示出统计学上的显著差异。在本研究中，NACT组的9例患者取得了满意的结果，非NACT组的8例患者术后取得了满意的结果，差异具有统计学意义（P = 0.001）。
结论
NACT可被视为口腔鳞状细胞癌患者的一种治疗选择，尤其是那些局部晚期肿瘤患者。需要进一步的前瞻性研究来验证这些在患者中的发现。
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