Ramani Pratibha, Ramasubramanian Abilasha, Kizhakkoottu Suvarna, Benitha Georgia
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2024 Jul-Sep;28(3):428-433. doi: 10.4103/jomfp.jomfp_26_24. Epub 2024 Oct 15.
Gingiva is a keratinised mucosa akin to the skin and is exposed in all modalities of treatment of oral cancer. Acquired lymphangiectasia are acquired dilatations of lymphatic channels secondary to an external cause. They are extremely rare in the oral cavity despite that oral cancers are treated with different treatment modalities.
The archives of the Oral and Maxillofacial Pathology Department of our institute were retrospectively reviewed from 2001 to 2021. Of the 9566 cases of oral biopsies, 4596 were confirmed cases of oral cancer including salivary gland carcinoma. These cases were followed up for the presence of post-neoplastic and post-therapeutic gingival lesions.
Of the 4596 patients, <10% patients reported recurrence or new primary of squamous cell carcinoma in the gingiva. Two patients were histopathologically diagnosed with acquired lymphangiectasia of gingiva after 12 years following surgery and radiation therapy as treatment for oral squamous cell carcinoma and mucoepidermoid carcinoma, which has been described in our report for the first time in the literature.
Even though acquired lymphangiectasia of gingiva is very rare, lymphatic malformations should be included in the clinical differential diagnosis of post-therapeutic gingival proliferative pathologies in order to ensure appropriate treatment and prevent over-diagnosis of this benign condition.
牙龈是一种类似于皮肤的角化黏膜，在口腔癌的所有治疗方式中均会暴露。后天性淋巴管扩张是继发于外部原因的淋巴管扩张。尽管口腔癌采用不同的治疗方式，但它们在口腔中极为罕见。
回顾性分析我院口腔颌面病理科2001年至2021年的档案。在9566例口腔活检病例中，4596例为确诊的口腔癌病例，包括涎腺癌。对这些病例进行随访，观察肿瘤切除后及治疗后牙龈病变的情况。
在4596例患者中，<10%的患者报告牙龈出现鳞状细胞癌复发或新的原发性病变。两名患者在接受手术和放射治疗作为口腔鳞状细胞癌和黏液表皮样癌的治疗后12年，经组织病理学诊断为后天性牙龈淋巴管扩张，这在我们的报告中是首次在文献中描述。
尽管后天性牙龈淋巴管扩张非常罕见，但在治疗后牙龈增生性病变的临床鉴别诊断中应包括淋巴管畸形，以确保适当的治疗并防止对这种良性疾病的过度诊断。
