Zubairi Maysaa B, Abd Abdulkareem H, Al-Lami Mohammed S
Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq.
Department of Pharmacology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1178-S1181. doi: 10.4103/jpbs.jpbs_172_23. Epub 2023 Jul 11.
To produce and analyze mupirocin nanomicelle (MP-NM) in insulin-based gel.
MP-NM was prepared using solvent evaporation with Tween 80 as a surfactant. HPMC polymer prepared gel. MP-NM was characterized by globular diameter, polydispersity index (PDI), pH, entrapment efficiency (EE), and transmission electron microscopy (TEM). NM MP release was studied .
The revolutionary MP-NM in insulin-based gel dissolves MP completely without precipitation due to its unique physical and chemical properties. MP had 8.64 ± 0.2 nm globular diameter, high EE (98.85 ± 0.01%), and normal homogeneous dispersion (PDI, 0.143 ± 0.003) in NM. MP's formula showed rapid first-order kinetics release.
To our knowledge, this is the first MP-NM nano-drug delivery system employing insulin-based gel. It has promising pre-clinical and clinical uses.
制备并分析基于胰岛素的凝胶中的莫匹罗星纳米胶束（MP-NM）。
以吐温80作为表面活性剂，采用溶剂蒸发法制备MP-NM。用羟丙甲纤维素聚合物制备凝胶。通过球状直径、多分散指数（PDI）、pH值、包封率（EE）和透射电子显微镜（TEM）对MP-NM进行表征。研究了纳米胶束中MP的释放情况。
基于胰岛素的凝胶中具有创新性的MP-NM因其独特的物理和化学性质，能使MP完全溶解而不沉淀。MP在纳米胶束中的球状直径为8.64±0.2纳米，包封率高（98.85±0.01%），且呈正常均匀分散（PDI为0.143±0.003）。MP配方显示出快速的一级动力学释放。
据我们所知，这是首个采用基于胰岛素的凝胶的MP-NM纳米药物递送系统。它具有良好的临床前和临床应用前景。
