用于皮肤科应用的基于胰岛素的凝胶中莫匹罗星纳米胶束的配方与表征
Formulation and Characterization of Mupirocin Nanomicelles in Insulin-Based Gel for Dermatological Application.
作者信息
Zubairi Maysaa B, Abd Abdulkareem H, Al-Lami Mohammed S
机构信息
Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq.
Department of Pharmacology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
出版信息
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1178-S1181. doi: 10.4103/jpbs.jpbs_172_23. Epub 2023 Jul 11.
AIM
To produce and analyze mupirocin nanomicelle (MP-NM) in insulin-based gel.
PROCEDURES
MP-NM was prepared using solvent evaporation with Tween 80 as a surfactant. HPMC polymer prepared gel. MP-NM was characterized by globular diameter, polydispersity index (PDI), pH, entrapment efficiency (EE), and transmission electron microscopy (TEM). NM MP release was studied .
RESULTS
The revolutionary MP-NM in insulin-based gel dissolves MP completely without precipitation due to its unique physical and chemical properties. MP had 8.64 ± 0.2 nm globular diameter, high EE (98.85 ± 0.01%), and normal homogeneous dispersion (PDI, 0.143 ± 0.003) in NM. MP's formula showed rapid first-order kinetics release.
CONCLUSION
To our knowledge, this is the first MP-NM nano-drug delivery system employing insulin-based gel. It has promising pre-clinical and clinical uses.
目的
制备并分析基于胰岛素的凝胶中的莫匹罗星纳米胶束（MP-NM）。
方法
以吐温80作为表面活性剂，采用溶剂蒸发法制备MP-NM。用羟丙甲纤维素聚合物制备凝胶。通过球状直径、多分散指数（PDI）、pH值、包封率（EE）和透射电子显微镜（TEM）对MP-NM进行表征。研究了纳米胶束中MP的释放情况。
结果
基于胰岛素的凝胶中具有创新性的MP-NM因其独特的物理和化学性质，能使MP完全溶解而不沉淀。MP在纳米胶束中的球状直径为8.64±0.2纳米，包封率高（98.85±0.01%），且呈正常均匀分散（PDI为0.143±0.003）。MP配方显示出快速的一级动力学释放。
结论
据我们所知，这是首个采用基于胰岛素的凝胶的MP-NM纳米药物递送系统。它具有良好的临床前和临床应用前景。
Zotero 插件