Laboratory of Membrane and Liposome Research, Department of Biochemistry, IMRIC, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
Department of Microbiology and Immunology, F. Edward Hèbert School of Medicine, Uniformed Services University, Bethesda, Maryland, USA.
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02377-17. Print 2018 Apr.
is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant .
是一种紧迫的抗生素耐药威胁。本研究确定了 94 株菌对莫匹罗星的 MIC 为 0.0039 至 0.0625μg/ml。未检测到与其他抗生素的交叉耐药性。莫匹罗星目前仅限于局部给药，当以纳米脂质体形式给药时，显示出注射活性。莫匹罗星的纳米脂质体制剂是治疗耐药性的潜在方法。
