Trowbridge E A, Warren C W, Martin J F
Clin Phys Physiol Meas. 1986 Aug;7(3):203-10. doi: 10.1088/0143-0815/7/3/001.
Platelet volume and count were measured by aperture impedance techniques in rats during acute thrombocytopenia 2, 6, 12 and 24 h and 3, 6, 9 and 11 days after a single injection of anti-platelet serum (APS). Platelet volume heterogeneity was quantified by four statistical parameters: the measure of central tendency, dispersion, asymmetry and convexity. None of the volume distributions, including the controls, was log Gaussian. Mean platelet volume increased for the first 6 h post APS and then started to decrease although the platelet count had not started to rise. There was an initial increase, followed by a smooth decrease to control values, in the coefficient of variation (suggesting an initial increased dispersion about the mean platelet volume) with concomitant decreases in asymmetry and convexity. In contrast the age of the platelets immediately after the APS injection must have a decreased dispersion about the mean age compared with control values. These facts are used to show that young platelets are not synonymous with large platelets even under the stress of acute thrombocytopenia and support the concept that thrombopoiesis is the dominant factor in determining platelet volume heterogeneity.
采用孔径阻抗技术，在大鼠单次注射抗血小板血清（APS）后2、6、12和24小时以及3、6、9和11天的急性血小板减少期间，测量血小板体积和计数。通过四个统计参数对血小板体积异质性进行量化：集中趋势、离散度、不对称性和凸度的测量值。包括对照组在内，所有体积分布均不符合对数高斯分布。APS注射后最初6小时平均血小板体积增加，随后开始下降，尽管血小板计数尚未开始上升。变异系数最初增加，随后平稳下降至对照值（表明围绕平均血小板体积的离散度最初增加），同时不对称性和凸度降低。相比之下，APS注射后立即测定的血小板平均年龄离散度肯定低于对照值。这些事实表明，即使在急性血小板减少的应激状态下，年轻血小板也不等同于大血小板，支持了血小板生成是决定血小板体积异质性的主导因素这一概念。
