Odell T T, Jackson C W, Murphy J R
Proc Soc Exp Biol Med. 1975 Mar;148(3):829-33. doi: 10.3181/00379727-148-38642.
After mild thrombocytopenia (about 50-100% of control platelet level), induced by injection of antiplatelet serum (APS), platelets increased at a fairly constant and moderate rate for about 4 days and reached a maximum count, greater than pretreatment levels, on the fifth day. After moderate to severe thrombocytopenia, an early moderate rate of platelet increase was succeeded within 2 days by a second more rapid rate that persisted for about 3 days. The maximum overshoot of the platelet count was usually less than twice the pretreatment level. After the largest doses of APS, the platelet count remained depressed for several days. Platelet response after acute thrombocytopenia induced with antiserum is therefore variable, depending on the level and duration of thrombocytopenia.
注射抗血小板血清（APS）诱导产生轻度血小板减少（约为对照血小板水平的50 - 100%）后，血小板以相当恒定且适度的速率增加约4天，并在第5天达到高于预处理水平的最大计数。在中度至重度血小板减少后，早期适度的血小板增加速率在2天内被第二种更快的速率所取代，这种更快的速率持续约3天。血小板计数的最大超调通常小于预处理水平的两倍。使用最大剂量的APS后，血小板计数会持续降低数天。因此，抗血清诱导的急性血小板减少后的血小板反应是可变的，这取决于血小板减少的程度和持续时间。
