Syreon Research Institute, Budapest, 1142, Hungary.
Fourth Department of Medicine, Jósa András Teaching Hospital, Nyíregyháza, 4400, Hungary.
Per Med. 2023 Jul;20(4):375-385. doi: 10.2217/pme-2023-0023. Epub 2023 Sep 11.
Maturity-onset diabetes of the young (MODY) is often misdiagnosed as Type I or II diabetes. This study was designed to assess the cost-effectiveness of MODY screening strategies in Hungary, which included a recent genetic test compared with no routine screening for MODY. A simulation model that combined a decision tree and an individual-level Markov model was constructed to assess the costs per quality-adjusted life year of screening strategies. Stratifying patients based on age and insulin treatment followed by a risk assessment questionnaire, a laboratory test and genetic testing was the most cost-effective strategy, saving EUR 12 and generating 0.0047 quality-adjusted life years gained per screened patient. This screening strategy could be considered for reimbursement, especially in countries with limited resources.
青少年发病的成年型糖尿病（MODY）常被误诊为 1 型或 2 型糖尿病。本研究旨在评估匈牙利 MODY 筛查策略的成本效益，该策略包括最近的一项遗传检测与常规 MODY 筛查相比。我们构建了一个结合决策树和个体水平马尔可夫模型的模拟模型，以评估筛查策略的每质量调整生命年成本。根据年龄和胰岛素治疗对患者进行分层，然后进行风险评估问卷、实验室检测和基因检测是最具成本效益的策略，可节省 12 欧元，并使每筛查 1 名患者获得 0.0047 个质量调整生命年。这种筛查策略可以考虑报销，特别是在资源有限的国家。
