• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

透明质酸填充剂注射血管并发症的管理策略:病例系列分析

Management strategies for vascular complications in hyaluronic acid filler injections: A case series analysis.

作者信息

Choi Sun Young, Shin Sun Hye, Seok Joon, Yoo Kwang Ho, Kim Beom Joon

机构信息

Department of Dermatology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong-si, Republic of Korea.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

出版信息

J Cosmet Dermatol. 2023 Dec;22(12):3261-3267. doi: 10.1111/jocd.15990. Epub 2023 Sep 11.

DOI:10.1111/jocd.15990
PMID:37694495
Abstract

BACKGROUND

As hyaluronic acid (HA) filler injections have become increasingly popular in the esthetic field, so have their side effects. Vascular complications, which can lead to skin necrosis or permanent scarring, are a particularly dangerous complication and occur when the filler is injected directly into a blood vessel or when an adjacent blood vessel is compressed by the filler material.

OBJECTIVE

To assess the clinical prognosis based on post-procedural management and clinical findings of HA filler vascular complications.

METHODS

Herein, we present a case series of vascular complications due to HA filler and evaluate their clinical prognosis based on post-procedural management and clinical findings. Clinical assessments were performed using Doppler ultrasound, thermography, and laboratory tests.

RESULTS

Factors including white blood cell count, the time of treatment initiation, and time of hyaluronidase injection influenced the clinical outcomes. Early recognition and prompt hyaluronidase injection proved crucial in preventing further damage and improving prognosis.

CONCLUSION

This case series highlights the importance of early detection and appropriate management of HA filler complications. Physicians should be aware of the potential risks associated with fillers and promptly address any adverse effects to achieve optimal clinical outcomes. Further studies are warranted to confirm these findings and refine treatment strategies for the HA filler complications.

摘要

背景

随着透明质酸(HA)填充剂注射在美容领域越来越受欢迎,其副作用也日益增多。血管并发症是一种特别危险的并发症,可导致皮肤坏死或永久性瘢痕形成,当填充剂直接注入血管或相邻血管被填充材料压迫时就会发生。

目的

根据HA填充剂血管并发症的术后管理和临床发现评估临床预后。

方法

在此,我们呈现一组HA填充剂所致血管并发症的病例系列,并根据术后管理和临床发现评估其临床预后。使用多普勒超声、热成像和实验室检查进行临床评估。

结果

包括白细胞计数、开始治疗时间和注射透明质酸酶时间等因素影响临床结果。早期识别并及时注射透明质酸酶对于防止进一步损伤和改善预后至关重要。

结论

该病例系列突出了早期发现和适当处理HA填充剂并发症的重要性。医生应意识到与填充剂相关的潜在风险,并及时处理任何不良反应以实现最佳临床结果。有必要进行进一步研究以证实这些发现并完善HA填充剂并发症的治疗策略。

相似文献

1
Management strategies for vascular complications in hyaluronic acid filler injections: A case series analysis.透明质酸填充剂注射血管并发症的管理策略:病例系列分析
J Cosmet Dermatol. 2023 Dec;22(12):3261-3267. doi: 10.1111/jocd.15990. Epub 2023 Sep 11.
2
A Scoping Review of Hyaluronidase Use in Managing the Complications of Aesthetic Interventions.透明质酸酶在处理美容干预并发症中的应用:范围综述
Aesthetic Plast Surg. 2024 Mar;48(6):1193-1209. doi: 10.1007/s00266-022-03207-9. Epub 2022 Dec 19.
3
Early ultrasound for diagnosis and treatment of vascular adverse events with hyaluronic acid fillers.早期超声用于透明质酸填充剂血管不良事件的诊断与治疗
J Am Acad Dermatol. 2023 Jan;88(1):79-85. doi: 10.1016/j.jaad.2019.07.032. Epub 2019 Jul 17.
4
Intralesional hyaluronidase injection to relieve non-hyaluronic acid filler-induced vascular adverse events.瘤内注射透明质酸酶以缓解非透明质酸填充剂引起的血管不良事件。
Int J Dermatol. 2024 Sep;63(9):1252-1255. doi: 10.1111/ijd.17355. Epub 2024 Jul 2.
5
Rehabilitation of the Dysmorphic Lower Eyelid From Hyaluronic Acid Filler: What to Do After a Good Periocular Treatment Goes Bad.透明质酸填充剂导致的畸形下眼睑修复:良好的眼周治疗效果不佳后该如何处理。
Aesthet Surg J. 2020 Jan 29;40(2):197-205. doi: 10.1093/asj/sjz078.
6
Ultrasound to improve the safety of hyaluronic acid filler treatments.超声检查可提高透明质酸填充治疗的安全性。
J Cosmet Dermatol. 2018 Dec;17(6):1019-1024. doi: 10.1111/jocd.12726. Epub 2018 Aug 6.
7
Delayed skin necrosis following hyaluronic acid filler injection: A case report.透明质酸填充剂注射后延迟性皮肤坏死:一例报告。
J Cosmet Dermatol. 2020 Mar;19(3):582-584. doi: 10.1111/jocd.13287. Epub 2020 Jan 11.
8
External vascular compression by hyaluronic acid filler documented with high-frequency ultrasound.高频超声记录透明质酸填充剂引起的外部血管压迫
J Cosmet Dermatol. 2019 Dec;18(6):1629-1631. doi: 10.1111/jocd.12901. Epub 2019 Mar 5.
9
Clinical Management of Nasal Skin Necrosis Caused by Hyaluronic Acid Filler.透明质酸填充剂所致鼻皮肤坏死的临床处理。
J Craniofac Surg. 2021;32(2):e120-e122. doi: 10.1097/SCS.0000000000006847.
10
Resolve and dissolve-An ultrasound-guided investigation on the effects of hyaluronidase on different soft tissue fillers.解决与溶解——透明质酸酶对不同软组织填充剂作用的超声引导研究。
J Cosmet Dermatol. 2024 Oct;23(10):3173-3181. doi: 10.1111/jocd.16393. Epub 2024 May 20.

引用本文的文献

1
A new protocol (THIS and FAT) for the treatment of filler-induced vascular occlusion: a case series.一种治疗填充剂所致血管阻塞的新方案(THIS和FAT):病例系列
Front Med (Lausanne). 2025 Jul 30;12:1585983. doi: 10.3389/fmed.2025.1585983. eCollection 2025.
2
A Review: Causes, Consequences, and Management Strategies of Facial Overfilling.综述:面部过度填充的原因、后果及管理策略
Clin Cosmet Investig Dermatol. 2025 Aug 4;18:1857-1864. doi: 10.2147/CCID.S539888. eCollection 2025.
3
Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes.
透明质酸与皮肤:其在衰老和伤口愈合过程中的作用
Gels. 2025 Apr 9;11(4):281. doi: 10.3390/gels11040281.
4
A Pilot One and Two-Year Prospective, Blinded Clinical Evaluation of Efficacy, and Safety of Combined Treatment With Crosslinked Hyaluronic Acid Dermal Filler and Barbed Polydioxanone Suspension Threads for Mid-Face Contour Enhancement.交联透明质酸真皮填充剂与倒刺聚二氧六环酮悬吊线联合治疗用于中面部轮廓改善的疗效和安全性的为期一年和两年的前瞻性、盲法临床试点评估。
J Cosmet Dermatol. 2025 Feb;24(2):e16700. doi: 10.1111/jocd.16700. Epub 2024 Dec 18.
5
Conventional High-Dose vs Low-Dose Hyaluronidase for Skin Necrosis after Hyaluronic Acid Fillers: A Systematic Review and Pilot Meta-Analysis.常规高剂量与低剂量透明质酸酶治疗透明质酸填充后皮肤坏死:系统评价和初步荟萃分析。
Aesthetic Plast Surg. 2024 Oct;48(19):3971-3978. doi: 10.1007/s00266-024-04334-1. Epub 2024 Aug 30.
6
The emerging topic of injected cosmetic fillers in the perinasal region of dromedary camels: ultrasonographic and radiographic verification.注射式美容填充物在单峰驼鼻部区域的新兴研究课题:超声和放射影像学验证。
Open Vet J. 2024 Mar;14(3):840-845. doi: 10.5455/OVJ.2024.v14.i3.11. Epub 2024 Mar 31.