Raut Samali S, Singh Neha R, Rane Bhushan R, Jain Ashish S
Department of Pharmaceutics, Shri D.D. Vispute College of Pharmacy and Research Center, New Panvel, Maharashtra, 410206, India
Pharm Nanotechnol. 2025 May 27. doi: 10.2174/2211738511666230908162410.
Benzoyl peroxide is a peroxide with antibacterial, irritating, keratolytic, comedolytic, and anti-inflammatory properties. When benzoyl peroxide is applied topically, it breaks down and releases oxygen, which kills the germs of Propionibacterium acnes. Benzoyl peroxide's irritating impact causes an increase in epithelial cell turnover, which causes the skin to peel and aids in the healing of comedones. Treatment for acne vulgaris involves the use of benzoyl peroxide.
The research is aimed at studying the formulation of Microsponge gel preparation of benzoyl peroxide by using Carbopol 934 as a gelling agent and evaluation of microsponge gel formulation for its physicochemical properties.
Microsponges of anti-acne agent benzoyl peroxide drug were prepared by quasi-emulsion method, and in-vitro drug release using a suitable membrane model using a simple diffusion cell.
Prior to drying, the microsponge was filtered and rinsed using distilled water. Formulation containing benzoyl peroxide and Eudragit RS100 with a ratio of 1:4 showed a high 87.5% drug content and 78.20 % yield. The drug content of the microsponge gel was found to be 84%. Microbiological study on S. aureus was conducted by the cylinder cup method and found good results. The in-vitro diffusion of microsponge formulations was sustained for 8 hours. The drug release rate for Eudragit RS- 100 was reported to be 88.87% after 8 hours based on the polymer: drug ratio (4:1).
The quasi-emulsion solvent diffusion method was used to successfully prepare benzoyl peroxide microsponges using Eudragit RS100, Ethyl Cellulose, and HPMC K4M as polymers. The formulations with the highest medication concentration were made with the porous polymer Eudragit RS100.
过氧化苯甲酰是一种具有抗菌、刺激、角质溶解、溶解粉刺和抗炎特性的过氧化物。局部应用过氧化苯甲酰时，它会分解并释放氧气，从而杀死痤疮丙酸杆菌。过氧化苯甲酰的刺激作用会导致上皮细胞更新增加，进而使皮肤脱皮并有助于粉刺的愈合。寻常痤疮的治疗涉及使用过氧化苯甲酰。
本研究旨在以卡波姆934为凝胶剂研究过氧化苯甲酰微球凝胶制剂的配方，并对微球凝胶配方的理化性质进行评价。
采用准乳液法制备抗痤疮药物过氧化苯甲酰微球，并使用简单扩散池通过合适的膜模型进行体外药物释放研究。
干燥前，微球用蒸馏水过滤并冲洗。过氧化苯甲酰与丙烯酸树脂RS100比例为1:4的制剂显示出较高的87.5%的药物含量和78.20%的产率。发现微球凝胶的药物含量为84%。采用圆筒杯法对金黄色葡萄球菌进行微生物学研究，结果良好。微球制剂的体外扩散持续了8小时。基于聚合物与药物比例（4:1），8小时后丙烯酸树脂RS - 100的药物释放率据报道为88.87%。
采用准乳液溶剂扩散法，以丙烯酸树脂RS100、乙基纤维素和羟丙甲纤维素K4M为聚合物成功制备了过氧化苯甲酰微球。药物浓度最高的制剂是用多孔聚合物丙烯酸树脂RS100制成的。
