Devsthali Vidyapeeth College of Pharmacy, Lalpur, Uttarakhand, India.
Gurugram University, Gurugram, Haryana, India.
J Cosmet Dermatol. 2022 Apr;21(4):1675-1687. doi: 10.1111/jocd.14274. Epub 2021 Jun 23.
The endeavor of this study is to prepare and developed a method for microsponge gel as a polyherbal formulation along with their evaluation methods for sunscreen properties.
Polyherbal extracts as an active component for preparing microsponge formulation used in ratio of a drug, i.e. Poly herbal extracts, ethyl cellulose used as polymer, Polyvinyl alcohol as an emulsifier present in the formulation was successfully obtained by using method quasi-emulsion solvent diffusion. The formulations prepared were considered for substantial characterization. The physical description of microsponge formulation, having a coating of Gel-3 exhibits more loading efficiency and production yield. The mentioned formulation of microsponge was formulated with the help of gel using carbopol and then test performed are pH, viscosity, spreadability, drug content, and in-vitro release. Most of the microsponge preparations are prepared by drug loading in it and the consequences are good to reproduce. The best formulation was prepared and then comparison study was done with one of the marketed simple gel of polyherbal extract and other one is microsponge loaded gel of polyherbal extract by using Franz diffusion cell.
The release profile details about that the microsponge loaded gels are showing excellent release rate while comparing to simple marketed gel of polyherbal extract.
本研究旨在制备和开发一种作为多草药制剂的微海绵凝胶方法，并对其防晒性能的评价方法进行评估。
多草药提取物作为制备微海绵制剂的活性成分，以药物的比例使用，即多草药提取物、乙基纤维素作为聚合物、聚乙烯醇作为乳化剂，通过准乳液溶剂扩散法成功获得。所制备的制剂被认为是实质性的特征描述。微海绵制剂的物理描述，具有 Gel-3 的涂层，表现出更高的载药效率和产率。所述微海绵制剂是使用卡波姆与凝胶一起配制的，然后进行 pH 值、粘度、铺展性、药物含量和体外释放等测试。大多数微海绵制剂是通过在其中加载药物来制备的，其结果是可以很好地重现。制备出最佳制剂后，通过Franz 扩散池对其进行了与市售的一种简单多草药提取物凝胶和另一种多草药提取物微海绵载药凝胶的比较研究。
释放曲线详细说明了微海绵载药凝胶在与市售的简单多草药提取物凝胶相比时具有优异的释放速率。
