Pech H J, Parsi R A
Cor Vasa. 1986;28(4):257-65.
In 10 patients with coronary heart disease (CHD), the effect of a single doses of slow-release isosorbide dinitrate (ISDN) on cardiac function was investigated. Haemo-dynamics was examined by right heart catheterization and thermodilution measurement of cardiac output. After placebo and after 2 and 6 hours with 40 mg ISDN, the heart rate (HR), cardiac index (CI), pressure values in the pulmonary artery (PASP, PAMP, PAEDP) and in the aorta (AoSP, AoMP, AoEDP) and systemic vascular resistance (SVR) were measured at rest and during bicycle ergometry. At rest, PASP and PAMP were significantly reduced only 6 hours after ISDN. Under exercise conditions, significantly reduced pressure values in the pulmonary artery were found 2 and 6 hours after ISDN. AoSP was likewise reduced 2 and 6 hours after ISDN. HR, CI and SVR showed no significant differences compared with placebo values. Thus, an effective reduction of left ventricular preload and afterload was seen in patients with CHD during bicycle ergometry.
在10例冠心病（CHD）患者中，研究了单剂量缓释硝酸异山梨酯（ISDN）对心功能的影响。通过右心导管检查和热稀释法测量心输出量来检测血流动力学。在服用安慰剂后以及服用40 mg ISDN后2小时和6小时，于静息状态和自行车测力计运动期间测量心率（HR）、心脏指数（CI）、肺动脉压力值（PASP、PAMP、PAEDP）、主动脉压力值（AoSP、AoMP、AoEDP）和全身血管阻力（SVR）。静息状态下，仅在服用ISDN 6小时后PASP和PAMP显著降低。在运动条件下，服用ISDN后2小时和6小时发现肺动脉压力值显著降低。ISDN服用后2小时和6小时AoSP同样降低。与安慰剂值相比，HR、CI和SVR无显著差异。因此，在冠心病患者进行自行车测力计运动期间，可见左心室前负荷和后负荷有效降低。
