Burmitskaya Yu V, Vasyukova O V, Okorokov P L, Zuraeva Z T, Bezlepkina O B
Endocrinology Research Center.
Probl Endokrinol (Mosk). 2023 Aug 30;69(4):87-95. doi: 10.14341/probl13250.
Adipomyokines are synthesized and secreted into the bloodstream by cells of both muscle and adipose tissue. They can have both a negative metabolic effect, acting as pro-inflammatory adipokines in obesity, and a positive one, increasing in response to physical exertion in the form of myokines.
To study the features of adipocytokine secretion in children with constitutionally exogenous obesity.
The study included 80 patients: 60 adolescents aged 15 [13; 16] years with constitutionally exogenous obesity SDS BMI: 3.0 [2.6; 3.3] and 20 control group children aged 16 [15; 17] years without excess weight SDS BMI: -0.3 [-1.25; 0.33]. Commercial enzyme immunoassay kits were used to determine the level of adipomyokines. The compositional composition of the body was evaluated by bioimpedance analysis (InBody 770 analyzer, South Korea) in the morning, on an empty stomach. Statistical processing was carried out using STATISTICA v.12.0 (StatSoft Inc., USA). The results are presented in the form of median (Me) and quartiles (Q1; Q3) corresponding to 25 and 75 percentiles. The critical significance level (p) was assumed to be <0.05.
Levels of IL-6 and irisin are statistically significantly higher in obese adolescents compared to the control group: 0.55 [0.226; 1.35] pg/ml vs 0.202 [0.128; 0.652] pg/ml (p=0.041) and 11.16 [6.6; 22.76] mcg/ml vs 7.36 [6.48; 9.68] mcg/ml (p=0.043), respectively. Concentrations of IL-6, myostatin and decorin increase with an increase in the degree of obesity: grade I vs III: 0.226 [0.224; 0.398] vs 0.80 [0.36; 1.81] pg/ml (p=0,0197), 25,85 [21,53; 28,23] vs 31.41 [24.36; 35.06] ng/ml (p=0.03), 4065.3 [3244.9; 5245.5] vs 5322.5 [4199.8; 7702.4] pg/ml (p=0.0376), respectively. In obese children, IL-6 levels positively correlate with BMI, SDS BMI and the amount of adipose tissue, and myostatin - with BMI and SDS BMI. The concentration of irisin in the blood serum is significantly higher in obese girls than in obese boys and healthy girls. Obese patients, compared with lean peers, are characterized by a statistically significantly higher content of both fat and lean mass. With the progression of obesity, there is a statistically significant increase in the ratio of fat to lean mass (I degree - 0.66 [0.56; 0.7], III - 0.78 [0.68; 0.98] (p=0.0073).
Patients with obesity and normal body weight have different levels of adipomyokines. An increase in the level of IL-6 with the progression of obesity is directly related to an increase in the content of adipose tissue. Further study of the features of adipocytokine secretion, their relationship with the features of the body composition and metabolic complications in obesity is required.
脂肪肌动蛋白由肌肉和脂肪组织细胞合成并分泌到血液中。它们既可以产生负面的代谢效应，在肥胖症中作为促炎脂肪因子起作用，也可以产生正面效应，作为肌动蛋白因体力活动而增加。
研究体质性外源性肥胖儿童脂肪细胞因子分泌的特征。
该研究纳入80例患者：60例15[13；16]岁的青少年，体质性外源性肥胖，SDS BMI：3.0[2.6；3.3]，以及20例16[15；17]岁无超重的对照组儿童，SDS BMI：-0.3[-1.25；0.33]。使用商用酶免疫分析试剂盒测定脂肪肌动蛋白水平。早晨空腹时通过生物电阻抗分析（韩国InBody 770分析仪）评估身体的组成成分。使用STATISTICA v.12.0（美国StatSoft公司）进行统计处理。结果以中位数（Me）和对应于第25和75百分位数的四分位数（Q1；Q3）的形式呈现。临界显著性水平（p）假定为<0.05。
与对照组相比，肥胖青少年中IL-6和鸢尾素水平在统计学上显著更高：分别为0.55[0.226；1.35]pg/ml对0.202[0.128；（此处原文可能有误，推测为0.652）]pg/ml（p = 0.041）和11.16[6.6；22.76]mcg/ml对7.36[6.48；9.68]mcg/ml（p = 0.043）。IL-6、肌肉生长抑制素和核心蛋白聚糖的浓度随着肥胖程度的增加而增加：I级对III级：0.226[0.224；0.398]对0.80[0.36；1.81]pg/ml（p = 0.0197），25.85[21.53；28.23]对31.41[24.36；35.06]ng/ml（p = 0.03），4065.3[3244.9；5245.5]对5322.5[4199.8；7702.4]pg/ml（p = 0.0376）。在肥胖儿童中，IL-6水平与BMI、SDS BMI和脂肪组织量呈正相关，而肌肉生长抑制素与BMI和SDS BMI呈正相关。肥胖女孩血清中鸢尾素的浓度显著高于肥胖男孩和健康女孩。与瘦的同龄人相比，肥胖患者的脂肪量和瘦体重在统计学上均显著更高。随着肥胖的进展，脂肪与瘦体重的比值在统计学上显著增加（I级 - （此处原文可能有误，推测为0.66[0.56；0.7]），III级 - 0.78[0.68；0.98]（p = 0.0073）。
肥胖患者和体重正常者的脂肪肌动蛋白水平不同。随着肥胖进展，IL-6水平的升高与脂肪组织含量的增加直接相关。需要进一步研究脂肪细胞因子分泌的特征、它们与肥胖症中身体组成特征和代谢并发症的关系。
