Department of Human Genetics, University of Chicago, Chicago, IL, USA
Department of Biology, Stanford University, Stanford, CA, USA
Behav Brain Sci. 2023 Sep 11;46:e199. doi: 10.1017/S0140525X22002278.
It has been known for decades that inference concerning genetic causes of human behavioral phenotypes cannot be legitimately made from correlations among relatives. We claim that these inferential difficulties cannot be overcome by assigning different names to causes inferred from within-family and population-level genome-wide association studies (GWASs). For educational attainment, for example, unraveling gene-environment interactions requires more than new names for causes.
几十年来,人们已经知道,不能根据亲属之间的相关性来合理推断人类行为表型的遗传原因。我们声称,通过给从家族内和人群全基因组关联研究(GWAS)中推断出的原因赋予不同的名称,并不能克服这些推理困难。例如,对于受教育程度,要解开基因-环境相互作用的谜团,需要的不仅仅是新的原因名称。