Department of Anesthesia, The First Affiliated Hospital of Soochow University, Suzhou, Jiang Su, China.
Department of Anesthesia, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
J Int Med Res. 2023 Sep;51(9):3000605231198386. doi: 10.1177/03000605231198386.
To investigate whether S-ketamine affects the Surgical Pleth Index (SPI) during video-assisted thoracoscopic surgery.
Eighty-four patients undergoing video-assisted thoracoscopic lung lobectomy were enrolled. They were randomly assigned to an S-ketamine group (group S) and an equivalent normal saline group (group N). SPI values were recorded; and pain score on a numerical rating scale (NRS), the consumption of opioids, rescue analgesia, and post-operative nausea and vomiting (PONV) were evaluated.
The SPI and heart rate of the S-ketamine group were significantly lower 30 minutes after the start of surgery and at the end. The NRS score was lower in the S-ketamine group 6 and 12 hours postoperatively, but there were no differences in mean blood pressure or the NRS score 24 and 48 hours postoperatively. Rescue analgesia was required less frequently by the S-ketamine group, but the incidence of PONV did not differ between the groups.
S-ketamine was associated with lower intraoperative SPI 30 minutes after the start and at the end of surgery. It also reduced opioid use intraoperatively and the NRS scores 6 and 12 hours postoperatively. Chinese Clinical Trial Registry (ChiCTR2000040012), 18/11/2020.
研究 S-氯胺酮是否会影响胸腔镜手术中的手术脉搏指数（SPI）。
共纳入 84 例行胸腔镜肺叶切除术的患者。他们被随机分为 S-氯胺酮组（S 组）和等效生理盐水组（N 组）。记录 SPI 值；并评估数字评分量表（NRS）上的疼痛评分、阿片类药物的消耗、解救性镇痛和术后恶心和呕吐（PONV）。
S-氯胺酮组在手术开始后 30 分钟和手术结束时的 SPI 和心率显著降低。S-氯胺酮组术后 6 小时和 12 小时的 NRS 评分较低，但术后 24 小时和 48 小时的平均血压或 NRS 评分无差异。S-氯胺酮组需要解救性镇痛的频率较低，但两组的 PONV 发生率无差异。
S-氯胺酮与手术开始后 30 分钟和手术结束时的术中 SPI 降低有关。它还减少了术中阿片类药物的使用以及术后 6 小时和 12 小时的 NRS 评分。中国临床试验注册中心（ChiCTR2000040012），2020 年 11 月 18 日。
