Department Virus Immunology, Leibniz Institute for Virology, Hamburg, Germany.
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Curr Top Microbiol Immunol. 2023;441:61-73. doi: 10.1007/978-3-031-35139-6_3.
Biological sex has wide-ranging impacts on HIV infection spanning differences in acquisition risk, the pathogenesis of untreated infection, impact of chronic treated disease and prospects for HIV eradication or functional cure. This chapter summarizes the scope of these differences and discusses several features of the immune response thought to contribute to the clinical outcomes.
生物学性别对 HIV 感染有广泛的影响,包括感染风险的差异、未经治疗感染的发病机制、慢性治疗疾病的影响以及 HIV 根除或功能性治愈的前景。本章总结了这些差异的范围,并讨论了几种被认为有助于临床结果的免疫反应特征。