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Loss of cyclophilin D prolyl isomerase activity desensitizes mitochondrial permeability transition pore opening in isolated cardiac mitochondria, but does not protect in myocardial ischemia-reperfusion injury.

作者信息

Casin Kevin M, Bustamante Moises, Amanakis Georgios, Sun Junhui, Liu Chengyu, Kitsis Richard N, Murphy Elizabeth

机构信息

Laboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.

Laboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.

出版信息

J Mol Cell Cardiol. 2023 Oct;183:67-69. doi: 10.1016/j.yjmcc.2023.09.003. Epub 2023 Sep 9.

DOI:10.1016/j.yjmcc.2023.09.003
PMID:37696137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10809717/
Abstract
摘要

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The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.腺嘌呤核苷酸转位酶家族通过线粒体通透性转换孔导致心脏缺血再灌注损伤，且不依赖亲环素D。
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本文引用的文献

1
Non-conventional mitochondrial permeability transition: Its regulation by mitochondrial dynamics.非传统的线粒体通透性转变：其受线粒体动力学的调节。
Biochim Biophys Acta Bioenerg. 2023 Jan 1;1864(1):148914. doi: 10.1016/j.bbabio.2022.148914. Epub 2022 Sep 3.
2
A 20/20 view of ANT function in mitochondrial biology and necrotic cell death.线粒体生物学和坏死性细胞死亡中 ANT 功能的 20/20 视角。
J Mol Cell Cardiol. 2020 Jul;144:A3-A13. doi: 10.1016/j.yjmcc.2020.05.012. Epub 2020 May 23.
3
Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.通过删除 ANT 家族和 CypD 来抑制线粒体通透性转换。
Sci Adv. 2019 Aug 28;5(8):eaaw4597. doi: 10.1126/sciadv.aaw4597. eCollection 2019 Aug.
4
ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore.ATP 合酶 C 亚基缺陷型线粒体具有小的环孢素 A 敏感通道，但缺乏通透性转换孔。
Cell Rep. 2019 Jan 2;26(1):11-17.e2. doi: 10.1016/j.celrep.2018.12.033.
5
CypD(-/-) hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism.CypD(-/-) 心脏中的蛋白水平发生改变，这些蛋白涉及三羧酸循环、支链氨基酸降解和丙酮酸代谢。
J Mol Cell Cardiol. 2013 Mar;56:81-90. doi: 10.1016/j.yjmcc.2012.12.004. Epub 2012 Dec 19.
6
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.亲环蛋白D的缺失揭示了线粒体通透性转换在细胞死亡中的关键作用。
Nature. 2005 Mar 31;434(7033):658-62. doi: 10.1038/nature03434.
7
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death.亲环素D依赖性线粒体通透性转换调节某些坏死性而非凋亡性细胞死亡。
Nature. 2005 Mar 31;434(7033):652-8. doi: 10.1038/nature03317.
8
Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization.线粒体靶向亲环蛋白D通过肽基脯氨酰异构化保护细胞免于细胞死亡。
J Biol Chem. 2002 Aug 23;277(34):31134-41. doi: 10.1074/jbc.M112035200. Epub 2002 Jun 19.
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Two modes of activation of the permeability transition pore: the role of mitochondrial cyclophilin.
Mol Cell Biochem. 1997 Sep;174(1-2):181-4.
10
Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition.人亲环蛋白A的活性位点突变体将肽基脯氨酰异构酶活性与环孢素A结合及钙调神经磷酸酶抑制作用分离开来。
Protein Sci. 1992 Sep;1(9):1092-9. doi: 10.1002/pro.5560010903.