亲环素 D 的生理功能和线粒体通透性转换孔。
Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.
机构信息
Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
出版信息
Circ J. 2013;77(5):1111-22. doi: 10.1253/circj.cj-13-0321. Epub 2013 Mar 29.
Abstract
This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition pore (MPTP) and subsequent effects on cardiovascular physiology and pathology. Although a great number of reviews have been written on the MPTP and its effects on cell death, we focus on the biology surrounding CypD itself and the non-cell death physiologic functions of the MPTP. A greater understanding of the physiologic functions of the MPTP and its regulation by CypD will likely suggest novel therapeutic approaches for cardiovascular disease, both dependent and independent of programmed necrotic cell death mechanisms.
摘要
这篇综述重点探讨了亲环素 D（CypD）作为线粒体通透性转换孔（MPTP）的主要介质的作用，以及其对心血管生理学和病理学的后续影响。尽管已经有大量关于 MPTP 及其对细胞死亡影响的综述文章，但我们重点关注 CypD 本身的生物学特性以及 MPTP 的非细胞死亡生理功能。更好地了解 MPTP 的生理功能及其受 CypD 调控的机制，可能会为依赖和不依赖程序性坏死细胞死亡机制的心血管疾病提供新的治疗方法。
相似文献
1
Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.亲环素 D 的生理功能和线粒体通透性转换孔。
Circ J. 2013;77(5):1111-22. doi: 10.1253/circj.cj-13-0321. Epub 2013 Mar 29.
2
Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore.亲环素 D 的半胱氨酸 203 对于亲环素 D 激活线粒体通透性转换孔至关重要。
J Biol Chem. 2011 Nov 18;286(46):40184-92. doi: 10.1074/jbc.M111.243469. Epub 2011 Sep 19.
3
Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning.线粒体亲环素 D 作为缺血预处理的关键介质。
Cardiovasc Res. 2010 Oct 1;88(1):67-74. doi: 10.1093/cvr/cvq113. Epub 2010 Apr 16.
4
The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.腺嘌呤核苷酸转位酶家族通过线粒体通透性转换孔导致心脏缺血再灌注损伤，且不依赖亲环素D。
Sci Adv. 2024 Dec 13;10(50):eadp7444. doi: 10.1126/sciadv.adp7444. Epub 2024 Dec 11.
5
Cyclophilin D and myocardial ischemia-reperfusion injury: a fresh perspective.亲环素 D 与心肌缺血再灌注损伤：新视角。
J Mol Cell Cardiol. 2015 Jan;78:80-9. doi: 10.1016/j.yjmcc.2014.09.026. Epub 2014 Oct 2.
6
Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion.丝氨酸 191 位点磷酸化环孢素 D 调节缺血再灌注后线粒体通透性转换孔的开放和细胞死亡。
Cell Death Dis. 2020 Aug 19;11(8):661. doi: 10.1038/s41419-020-02864-5.
7
Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure.线粒体亲环素 D 作为心肌梗死后心力衰竭的潜在治疗靶点。
J Cell Mol Med. 2011 Nov;15(11):2443-51. doi: 10.1111/j.1582-4934.2010.01235.x.
8
The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore.线粒体 ATP 合酶是线粒体通透性转换孔的负调节剂。
Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2303713120. doi: 10.1073/pnas.2303713120. Epub 2023 Dec 13.
9
HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart.HAX-1调节心脏中环孢素-D水平及线粒体通透性转换孔。
Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6466-75. doi: 10.1073/pnas.1508760112. Epub 2015 Nov 9.
10
The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection.线粒体通透性转换孔：分子本质及其作为心脏保护靶点的作用
J Mol Cell Cardiol. 2015 Jan;78:100-6. doi: 10.1016/j.yjmcc.2014.09.023. Epub 2014 Sep 28.
引用本文的文献
1
Broad-Spectrum Antiviral Activity of Cyclophilin Inhibitors Against Coronaviruses: A Systematic Review.亲环素抑制剂对冠状病毒的广谱抗病毒活性：一项系统综述
Int J Mol Sci. 2025 Aug 15;26(16):7900. doi: 10.3390/ijms26167900.
2
The role of mitochondria-associated ER membranes in disease pathology: protein complex and therapeutic targets.线粒体相关内质网膜在疾病病理学中的作用：蛋白质复合物与治疗靶点。
Front Cell Dev Biol. 2025 Jun 30;13:1629568. doi: 10.3389/fcell.2025.1629568. eCollection 2025.
3
Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies.线粒体相关内质网膜与心肌缺血：从分子机制到治疗策略
J Transl Med. 2025 Mar 6;23(1):277. doi: 10.1186/s12967-025-06262-3.
4
Depletion of Mitochondrial Cyclophilin D in Endothelial and Smooth Muscle Cells Attenuates Vascular Dysfunction and Hypertension.内皮细胞和平滑肌细胞中线粒体亲环素D的缺失可减轻血管功能障碍和高血压。
Function (Oxf). 2025 Mar 24;6(2). doi: 10.1093/function/zqaf006.
5
Genetic Markers of Postmortem Brain Iron.死后脑铁的遗传标记
J Neurochem. 2025 Feb;169(2):e16309. doi: 10.1111/jnc.16309.
6
Exploration of the Role of Cyclophilins in Established Hepatitis B and C Infections.亲环素在慢性乙型和丙型肝炎感染中的作用探究
Viruses. 2024 Dec 25;17(1):11. doi: 10.3390/v17010011.
7
The cyclophilin D (CypD) of Toxoplasma gondii is involved in the parasite's response to oxidative stress damage.刚地弓形虫的亲环蛋白D（CypD）参与寄生虫对氧化应激损伤的反应。
Parasitol Res. 2024 Dec 4;123(12):404. doi: 10.1007/s00436-024-08412-w.
8
Cyclophilin D plays a critical role in the survival of senescent cells.亲环素D在衰老细胞的存活中起关键作用。
EMBO J. 2024 Dec;43(23):5972-6000. doi: 10.1038/s44318-024-00259-2. Epub 2024 Oct 24.
9
RNA-seq analysis of mitochondria-related genes regulated by AMPK in the human trophoblast cell line BeWo.在人滋养层细胞系BeWo中对受AMPK调控的线粒体相关基因进行RNA测序分析。
Animal Model Exp Med. 2025 Apr;8(4):649-661. doi: 10.1002/ame2.12475. Epub 2024 Oct 24.
10
Melatonin Alleviates Liver Mitochondrial Dysfunction in Leptin-Deficient Mice.褪黑素可减轻瘦素缺乏小鼠的肝脏线粒体功能障碍。
Int J Mol Sci. 2024 Aug 8;25(16):8677. doi: 10.3390/ijms25168677.
本文引用的文献
1
Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition.FO ATP 合酶 C 亚基在线粒体通透性转换中的作用。
Cell Cycle. 2013 Feb 15;12(4):674-83. doi: 10.4161/cc.23599. Epub 2013 Jan 23.
2
The mitochondrial transporter family SLC25: identification, properties and physiopathology.线粒体转运蛋白家族 SLC25：鉴定、特性和病理生理学。
Mol Aspects Med. 2013 Apr-Jun;34(2-3):465-84. doi: 10.1016/j.mam.2012.05.005. Epub 2012 Dec 23.
3
CypD(-/-) hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism.CypD(-/-) 心脏中的蛋白水平发生改变，这些蛋白涉及三羧酸循环、支链氨基酸降解和丙酮酸代谢。
J Mol Cell Cardiol. 2013 Mar;56:81-90. doi: 10.1016/j.yjmcc.2012.12.004. Epub 2012 Dec 19.
4
Cyclophilin inhibitors: an emerging class of therapeutics for the treatment of chronic hepatitis C infection.亲环素抑制剂：治疗慢性丙型肝炎感染的新兴治疗类别。
Viruses. 2012 Oct 29;4(11):2558-77. doi: 10.3390/v4112558.
5
CDD: conserved domains and protein three-dimensional structure.CDD：保守结构域和蛋白质三维结构。
Nucleic Acids Res. 2013 Jan;41(Database issue):D348-52. doi: 10.1093/nar/gks1243. Epub 2012 Nov 28.
6
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.MCUR1 是线粒体钙摄取的必需组成部分，可调节细胞代谢。
Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25.
7
Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis?p53是长期以来一直在寻找的亲环蛋白D调节的线粒体通透性转换孔形成和坏死的分子触发因素吗？
Circ Res. 2012 Oct 26;111(10):1258-60. doi: 10.1161/CIRCRESAHA.112.280990.
8
Mitochondrial control of cellular life, stress, and death.线粒体对细胞生命、应激和死亡的控制。
Circ Res. 2012 Oct 12;111(9):1198-207. doi: 10.1161/CIRCRESAHA.112.268946.
9
p53 opens the mitochondrial permeability transition pore to trigger necrosis.p53 打开线粒体通透性转换孔以引发细胞坏死。
Cell. 2012 Jun 22;149(7):1536-48. doi: 10.1016/j.cell.2012.05.014.
10
Mechanisms of cell death in heart disease.心脏病中细胞死亡的机制。
Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1552-62. doi: 10.1161/ATVBAHA.111.224915. Epub 2012 May 17.
Zotero 插件