Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Circ J. 2013;77(5):1111-22. doi: 10.1253/circj.cj-13-0321. Epub 2013 Mar 29.
This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition pore (MPTP) and subsequent effects on cardiovascular physiology and pathology. Although a great number of reviews have been written on the MPTP and its effects on cell death, we focus on the biology surrounding CypD itself and the non-cell death physiologic functions of the MPTP. A greater understanding of the physiologic functions of the MPTP and its regulation by CypD will likely suggest novel therapeutic approaches for cardiovascular disease, both dependent and independent of programmed necrotic cell death mechanisms.
这篇综述重点探讨了亲环素 D（CypD）作为线粒体通透性转换孔（MPTP）的主要介质的作用，以及其对心血管生理学和病理学的后续影响。尽管已经有大量关于 MPTP 及其对细胞死亡影响的综述文章，但我们重点关注 CypD 本身的生物学特性以及 MPTP 的非细胞死亡生理功能。更好地了解 MPTP 的生理功能及其受 CypD 调控的机制，可能会为依赖和不依赖程序性坏死细胞死亡机制的心血管疾病提供新的治疗方法。
