Huang Youfang, Zhang Yueyue, Yu Yilin, Song Xiaochong, Huang Xiaojia
Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China.
Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China.
Food Chem. 2024 Feb 15;434:137412. doi: 10.1016/j.foodchem.2023.137412. Epub 2023 Sep 9.
Specific capture is a beneficial tactic in simultaneous monitoring of sulfonamides (SAs) and quinolones (QLs). For this purpose, a new magnetic molecularly imprinted adsorbent based on double-template molecules (DT-MIP@MNA) was facilely prepared by "one-pot" hydrothermal technique and utilized as the adsorbent of magnetic solid-phase extraction (MSPE). Molecular simulation technique was employed to quickly screen functional monomer. The recognition factors of prepared adsorbent towards templates sulfamethazine and nalidixic acid were 5.89 and 2.90, respectively, and the corresponding adsorption capacities were as high as 8.85 mg/g and 8.97 mg/g, respectively. Under the optimized parameters, the proposed DT-MIP@MNA/MSPE was combined with HPLC to simultaneously and selectively monitor trace SAs and QLs residuals in water and milk samples. The achieved limits of detection were 0.012-0.028 μg/L and 0.015-0.032 μg/kg for water and milk samples, respectively. The current supplied a sensitive, reliable and anti-interference method for simultaneously monitoring trace SAs and QLs in food.
特异性捕获是同时监测磺胺类药物（SAs）和喹诺酮类药物（QLs）的一种有效策略。为此，通过“一锅法”水热技术简便地制备了一种基于双模板分子的新型磁性分子印迹吸附剂（DT-MIP@MNA），并将其用作磁性固相萃取（MSPE）的吸附剂。采用分子模拟技术快速筛选功能单体。制备的吸附剂对模板磺胺二甲嘧啶和萘啶酸的识别因子分别为5.89和2.90，相应的吸附容量分别高达8.85 mg/g和8.97 mg/g。在优化的参数下，所提出的DT-MIP@MNA/MSPE与高效液相色谱法相结合，用于同时选择性监测水和牛奶样品中的痕量SAs和QLs残留。水和牛奶样品的检测限分别为0.012 - 0.028 μg/L和0.015 - 0.032 μg/kg。该方法为同时监测食品中的痕量SAs和QLs提供了一种灵敏、可靠且抗干扰的方法。
