Division of Animal Sciences, University of Missouri, Columbia, MO 65211, United States.
Division of Animal Sciences, University of Missouri, Columbia, MO 65211, United States; MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, United States; Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO 65211, United States.
Gene. 2023 Dec 15;887:147788. doi: 10.1016/j.gene.2023.147788. Epub 2023 Sep 9.
Epigenetic memory is an emerging concept that refers to the process in which epigenetic changes occurring early-in life can lead to long-term programs of gene regulation in time and space. By leveraging neural network regression modeling of DNA methylation data in pigs, we show that specific methylations in the adult blood can reliably predict methylation changes that occurred in the fetal brain. Genes associated with these methylations represented known markers of specific cell types of blood including bone marrow hematopoietic progenitor cells, and ependymal and oligodendrocyte cells of brain. This suggested that methylation changes that occurred in the developing brain were maintained as an epigenetic memory in the blood through the adult life.
表观遗传记忆是一个新兴概念，是指生命早期发生的表观遗传变化可以导致基因在时间和空间上的长期调控程序。通过对猪的 DNA 甲基化数据进行神经网络回归建模，我们表明，成年血液中的特定甲基化可以可靠地预测胎儿大脑中发生的甲基化变化。与这些甲基化相关的基因代表了血液中特定细胞类型的已知标志物，包括骨髓造血祖细胞以及脑内的室管膜细胞和少突胶质细胞。这表明，在发育中的大脑中发生的甲基化变化在成年期通过血液作为表观遗传记忆得以维持。
