German Cancer Research Center (DKFZ), Heidelberg, Division of Metabolic Crosstalk in Cancer and the German Cancer Consortium (DKTK), DKFZ Core Center Heidelberg, 69120 Heidelberg, Germany; Neurology Clinic and National Center for Tumor Diseases, 69120 Heidelberg, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Division of Metabolic Crosstalk in Cancer and the German Cancer Consortium (DKTK), DKFZ Core Center Heidelberg, 69120 Heidelberg, Germany; Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany.
Biochem Pharmacol. 2023 Oct;216:115798. doi: 10.1016/j.bcp.2023.115798. Epub 2023 Sep 9.
The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network that plays a critical role in various biological processes, including cellular metabolism, development, and immune responses. The complexity of AHR signaling arises from multiple factors, including the diverse ligands that activate the receptor, the expression level of AHR itself, and its interaction with the AHR nuclear translocator (ARNT). Additionally, the AHR crosstalks with the AHR repressor (AHRR) or other transcription factors and signaling pathways and it can also mediate non-genomic effects. Finally, posttranslational modifications of the AHR and its interaction partners, epigenetic regulation of AHR and its target genes, as well as AHR-mediated induction of enzymes that degrade AHR-activating ligands may contribute to the context-specificity of AHR activation. Understanding the complexity of AHR signaling is crucial for deciphering its physiological and pathological roles and developing therapeutic strategies targeting this pathway. Ongoing research continues to unravel the intricacies of AHR signaling, shedding light on the regulatory mechanisms controlling its diverse functions.
芳香烃受体 (AHR) 信号通路是一个复杂的调节网络，在细胞代谢、发育和免疫反应等多种生物学过程中发挥着关键作用。AHR 信号通路的复杂性源于多个因素，包括激活受体的多种配体、AHR 自身的表达水平及其与 AHR 核转位蛋白 (ARNT) 的相互作用。此外，AHR 还与 AHR 阻遏物 (AHRR) 或其他转录因子和信号通路相互作用，并且可以介导非基因组效应。最后，AHR 及其相互作用伙伴的翻译后修饰、AHR 和其靶基因的表观遗传调控以及 AHR 介导的降解 AHR 激活配体的酶的诱导可能有助于 AHR 激活的特定条件。理解 AHR 信号通路的复杂性对于破译其生理和病理作用以及开发针对该途径的治疗策略至关重要。正在进行的研究继续揭示 AHR 信号通路的复杂性，阐明控制其多种功能的调节机制。
