Johnson D A, Winters C, Drane W E, Cattau E L, Karvelis K C, Silverman E D, Spurling T J, Chobanian S J, Dubois A
Dig Dis Sci. 1986 Nov;31(11):1217-20. doi: 10.1007/BF01296522.
Delayed gastric emptying as a pathophysiologic factor in patients with gastroesophageal reflux (GER) is controversial. In order to further evaluate this question, we studied a population with severe reflux, specifically, patients with Barrett's esophagus. Solid-phase gastric emptying was measured in 17 patients and in 17 healthy volunteers using radionuclide imaging. Gastric emptying was variable among these patients with 70% normal, 18% rapid, and only 12% slow studies. From these observations, we conclude that delayed gastric emptying is unlikely to be a major factor in the pathogenesis of Barrett's esophagus.
