Rothberg A D, Miot A, Leiman G
Diagn Cytopathol. 1986 Sep;2(3):212-6. doi: 10.1002/dc.2840020307.
Sequential tracheal aspirates from 39 neonates with hyaline membrane disease were examined to correlate cytological findings with the development of bronchopulmonary dysplasia (BPD). A total of 224 tracheal aspirates were examined from these infants, 15 of whom developed BPD as diagnosed by conventional clinical and radiological criteria. Hyperplastic and metaplastic epithelial changes were observed in all infants studied. Dysplastic changes occurred in 14 of 15 who developed BPD, and 14 of 24 who had a normal outcome (P less than 0.02). The exfoliation of dysplastic metaplastic bronchial cells was thus 95% specific and 71% sensitive for the subsequent development of BPD. Factors associated with the development of BPD were very low birth weight and gestational age, persistence of a patent ductus arteriosus, high peak inspiratory pressure (cm of H2O/kg), prolonged assisted ventilation, and rapidity of development of class III (dysplastic) changes in tracheal aspirates.
对39例患有透明膜病的新生儿的系列气管吸出物进行检查，以将细胞学检查结果与支气管肺发育不良（BPD）的发展相关联。对这些婴儿共检查了224份气管吸出物，其中15例根据传统临床和放射学标准诊断为发生了BPD。在所有研究的婴儿中均观察到增生性和化生上皮改变。15例发生BPD的婴儿中有14例出现发育异常改变，24例结局正常的婴儿中有14例出现发育异常改变（P<0.02）。因此，发育异常化生支气管细胞的脱落对BPD随后发展的特异性为95%，敏感性为71%。与BPD发生相关的因素包括极低出生体重和胎龄、动脉导管未闭持续存在、吸气峰压高（厘米水柱/千克）、辅助通气时间延长以及气管吸出物中III级（发育异常）改变的发展速度。
