Rybak M J, Boike S C
Drug Intell Clin Pharm. 1986 Oct;20(10):757-61. doi: 10.1177/106002808602001003.
Vancomycin is an effective and widely used antistaphylococcal antibiotic. Despite several decades of use, however, our knowledge of the toxicologic and pharmacokinetic properties of vancomycin remains incomplete. This review summarizes current information regarding the adverse reactions and pharmacokinetics of vancomycin. Although there have been reports of side effects with vancomycin, these effects tend to be infrequent, easily managed, and reversible. Several methods for adjustment of vancomycin therapy have been recommended. The relationship between serum concentrations of vancomycin and the occurrence of ototoxicity or nephrotoxicity has not been well established. However, because of large interpatient variations in pharmacokinetic parameters, it seems preferable to individualize vancomycin therapy based on serum concentration data.
万古霉素是一种有效且广泛使用的抗葡萄球菌抗生素。然而，尽管已使用了数十年，但我们对万古霉素的毒理学和药代动力学特性的了解仍不完整。本综述总结了有关万古霉素不良反应和药代动力学的当前信息。尽管有万古霉素副作用的报道，但这些效应往往不常见、易于处理且可逆。已推荐了几种调整万古霉素治疗的方法。万古霉素血清浓度与耳毒性或肾毒性发生之间的关系尚未明确确立。然而，由于患者间药代动力学参数差异很大，基于血清浓度数据对万古霉素治疗进行个体化似乎更为可取。
