巴基斯坦人群中灭活 COVID-19 疫苗的短期副作用：一项基于调查的横断面研究。

Short Term Side Effects Of Inactivated COVID-19 Vaccines Among Pakistani Population: A Survey-Based Cross-Sectional Study.

机构信息

Department of Medical Unit I, Civil Hospital, Dow University of Health Sciences, Karachi, Pakistan.

Fifth Year MBBS Student, Dow University of Health Sciences, Karachi, Pakistan.

出版信息

J Pak Med Assoc. 2023 Aug;73(8):1592-1597. doi: 10.47391/JPMA.6885.

DOI:10.47391/JPMA.6885

PMID:37697748

Abstract

OBJECTIVES

To assess the short-term adverse effects of two inactivated coronavirus disease-2019 vaccines, and the demographic factors associated with such events.

METHODS

The cross-sectional study was conducted in Karachi from August to October 2021 after approval from the ethics review board of Dow University of Health Sciences, Karachi, and comprised adults of either gender who had received at least one dose of either Sinopharm or CoronaVac vaccine. Data was collected using online and printed survey forms. The questionnaire investigated the symptoms experienced by the participants after the administration of the vaccine dose. Data was analysed using SPSS 22.

RESULTS

Of the 1000 survey forms filled, 896 were analysed; 505(56.4%) women and 391(43.6%) men were included in the study. Most of the participants were aged 18-30 years 644(71.9%). Overall, 581(64.8%) subjects had received Sinopharm vaccine, and 315(35.2%) received CoronaVac. The incidence of side effects after the first and second dose respectively was 63.3% (368 out of 581) and 55.2% (239 out of 433) for Sinopharm and 65.4% (206 out of 315) and 61.4% (89 out of 145) for CoronaVac. The factors associated with a higher risk of side effects were female gender and young age (p<0.05).

CONCLUSIONS

Most of the reported symptoms were minor in nature, like pain at the injection site, and women and those of young age reported such symptoms more than men and the elderly.

摘要

目的

评估两种已灭活的 2019 冠状病毒疾病疫苗的短期不良影响，以及与这些事件相关的人口统计学因素。

方法

本横断面研究于 2021 年 8 月至 10 月在卡拉奇进行，经卡拉奇道大学健康科学伦理审查委员会批准，纳入至少接种过一剂国药或科兴疫苗的成年男女。使用在线和纸质调查问卷收集数据。问卷调查了参与者在接种疫苗后出现的症状。使用 SPSS 22 进行数据分析。

结果

在填写的 1000 份调查问卷中，对 896 份进行了分析；研究纳入 505 名（56.4%）女性和 391 名（43.6%）男性。大多数参与者年龄在 18-30 岁，共 644 人（71.9%）。总体而言，581 名（64.8%）受试者接种了国药疫苗，315 名（35.2%）接种了科兴疫苗。接种第一剂和第二剂后不良反应的发生率分别为 63.3%（581 例中的 368 例）和 55.2%（433 例中的 239 例），接种第一剂和第二剂后不良反应的发生率分别为 65.4%（315 例中的 206 例）和 61.4%（145 例中的 89 例）。与不良反应风险增加相关的因素为女性和年轻（p<0.05）。