Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Center for Cognitive Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
CNS Neurosci Ther. 2024 Mar;30(3):e14440. doi: 10.1111/cns.14440. Epub 2023 Sep 12.
To explore the roles of apolipoprotein E (APOE) ε4 on the neuropathology and neuroinflammation in Alzheimer's disease (AD) patients.
AD patients were divided into the APOE ε4 carrier and the APOE ε4 non-carrier groups according to APOE genotype. Demographic information, cognitive function, the levels of neuropathological proteins and neuroinflammatory factors in cerebrospinal fluid (CSF) were compared between the two groups, and their correlations were subsequently analyzed.
β amyloid protein (Aβ) level from the APOE ε4 carrier group was significantly lower than that from the non-carrier group (p = 0.023), which was associated with worse cognitive function. The nitric oxide (NO) level was significantly elevated in the APOE ε4 carrier group compared to the non-carrier group (p = 0.016), which was significantly and positively correlated with the Trail Making Test (TMT)-A-time (r = 0.21, p = 0.026) and TMT-B-time (r = 0.38, p < 0.01).
APOE ε4 is associated with poorer cognition, particularly the early symptoms of memory, language, and attention. APOE ε4 is associated with lower Aβ level, and the more numbers of APOE ε4 are carried, the lower level of Aβ is measured. APOE ε4 is associated with elevated NO level, which is linked to the impaired attention and executive function.
探讨载脂蛋白 E（APOE）ε4 在阿尔茨海默病（AD）患者神经病理学和神经炎症中的作用。
根据 APOE 基因型将 AD 患者分为 APOE ε4 携带者和非携带者组。比较两组患者的人口统计学信息、认知功能、脑脊液（CSF）中神经病理蛋白和神经炎症因子水平，并分析其相关性。
APOE ε4 携带者组β淀粉样蛋白（Aβ）水平显著低于非携带者组（p=0.023），且与认知功能较差相关。与非携带者组相比，APOE ε4 携带者组的一氧化氮（NO）水平显著升高（p=0.016），且与连线测验 A 时间（TMT-A-time，r=0.21，p=0.026）和 TMT-B 时间（r=0.38，p<0.01）呈显著正相关。
APOE ε4 与认知功能下降有关，尤其是记忆、语言和注意力等早期症状。APOE ε4 与 Aβ 水平降低有关，携带的 APOE ε4 数量越多，Aβ 水平越低。APOE ε4 与 NO 水平升高有关，与注意力和执行功能受损有关。
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